Synthesis and antitumor activity of some novel quinazoline derivatives bearing the biologically active thione moiety
The reactivity of isothiocyanate 1 towards some nitrogen nucleophils was investigated. Thus, interaction of 1 with p-flouroaniline, benzylamine, 2-aminopyridine, and 4-aminoantipyrine yielded the corresponding quinazoline derivatives 37, respectively. Tri
Ghorab, Moustafa M.,Barakat, Saber El-Sayed,Saker, Helmy M.,Abd Rabo, Mahmoud M.
p. 665 - 670
(2008/02/12)
Synthesis of benzimidazo[1,2-c]quinazoline-6(5H)-thiones
New benzimidazo[1,2-c]quinazoline-6(5H)-thiones were prepared by cyclization of 3-(2-aminophenyl)quinazoline-2-thioxo-4-ones. Alkylation of these products led to S-alkyl derivatives of benzimidazo[1,2-c]quinazolines.