422568-68-1Relevant articles and documents
Preparation of labeled aromatic amino acids: Via late-stage18F-fluorination of chiral nickel and copper complexes
Craig, Austin,Kolks, Niklas,Urusova, Elizaveta A.,Zischler, Johannes,Brugger, Melanie,Endepols, Heike,Neumaier, Bernd,Zlatopolskiy, Boris D.
, p. 9505 - 9508 (2020/09/03)
A general protocol for the preparation of 18F-labeled AAAs and α-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. The chiral auxiliaries are easily accessible from commercially available starting materials in a few synthetic steps. The versatility of the method was demonstrated by the high-yielding preparation of a series of [18F]F-AAAs and the successful implementation of the protocol into automated radiosynthesis modules. This journal is
A new approach to the efficient method for the asymmetric synthesis of (S)-O-, M-, P-fluorophenylalanines and their 2-methyl-substituted analogs
Saghiyan, Ashot S.,Petrosyan, Satenik G.,Manasyan, Luiza L.,Dadayan, Slavik A.,Geolchanyan, Arpine V.,Panosyan, Henry A.,Maleev, Victor I.,Khrustalev, Victor N.
scheme or table, p. 493 - 506 (2011/04/16)
The reactions of asymmetric C-alkylation of glycine and alanine in NiII complexes of their Schiff's bases with modified chiral auxiliaries (S)-2-N-[(N0-2-chlorobenzylprolyl)- amino]benzophenone and (S)-2-N-[N′-(3, 4-dimethylbenzylprolyl)amino]benzophenone by fluorine-substituted benzyl halogenides have been studied. As a result, a highly stereoselective and relatively rapid method for the asymmetric synthesis of (S)-o-, m-, p-fluorophenylalanines and their 2-methyl substituted analogs has been developed.
Chiral salen-metal complexes as novel catalysts for asymmetric phase transfer alkylations
Belokon, Yuri N.,North, Michael,Kublitski, Vadim S.,Ikonnikov, Nikolai S.,Krasik, Pavel E.,Maleev, Viktor I.
, p. 6105 - 6108 (2007/10/03)
Chiral, salen-metal complexes have been tested as catalysts for the C- alkylation of aldimine Schiff's bases of alanine esters with alkyl bromides under phase-transfer conditions (solid sodium hydroxide, toluene, ambient temperature, 1-10% of the catalyst
No-carrier-added asymmetric synthesis of α-methyl-α-amino acids labelled with fluorine-18
Damhaut, Philippe,Lemaire, Christian,Plenevaux, Alain,Brihaye, Claude,Christiaens, Leon,Comar, Dominique
, p. 5785 - 5796 (2007/10/03)
Various [18F]fluoro aromatic α-methyl-L-amino acids T1 have been synthesized with high enantiomeric purity (ee > 97%). These new radiopharmaceuticals for Positron Emission Tomography (PET), potential inhibitors of enzymatic functions, were regi
Asymmetric synthesis of organoelement analogues of natural products; Part 12: General method for the asymmetric synthesis of fluorine-containing phenylalanines and α-methyl(phenyl)alanines via alkylation of the chiral nickel(II) Schiff's base complexes of
Kukhar,Belokon,Soloshonok,Svistunova Yu.,Rozhenko,Kuz'mina
, p. 117 - 120 (2007/10/02)
Nickel(II) complexes of Schiff's bases derived from (S)-o-[(N-benzyl]prolyl)amino]benzophenone [N-(2-benzoylphenyl)-1-benzylpyrrolidine-2-carboxamide] (BBP) and glycine or alanine have been used for asymmetric synthesis of fluoro (S)-phenylalanines and (S
ASYMMETRIC SYNTHESIS OF HETEROORGANIC ANALOGS OF NATURAL COMPOUNDS. 2. A CONVENIENT PREPARATIVE METHOD FOR THE SYNTHESIS OF ENANTIOMERICALLY PURE (S)-(-)-o-, m-, and p-FLUOROPHENYLALANINES AND THEIR 2-METHYL-SUBSTITUTED ANALOGS.
Soloshonok, V. A.,Belokon', Yu. N.,Kukhar', V. P.,Chernoglazova, N. I.,Saporovskaya, M. B.,et al.
, p. 1479 - 1485 (2007/10/02)
A convenient preparative method for the synthesis of the enantiomerically pure o-, m-, and p-fluorophenylalanines and their α-methyl-substituted analogs by means of the alkylation with the corresponding fluorine-containing benzyl chlorides of glycine and
RESOLUTION OF α-METHYL AMINO ESTERS BY CHYMOTRYPSIN
Anantharamaiah, G. M.,Roeske, Roger W.
, p. 3335 - 3336 (2007/10/02)
The resolution of DL-α-MeTrp-OMe HCl, DL-α-MePhe-OMe HCl and DL-α-Me-pF-Phe-OMe HCl have been achieved using α-chymotrypsin at pH 5.0.
