126402-81-1

Basic information

• Product Name: isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate
• Synonyms: isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate
• CAS NO: 126402-81-1
• Molecular Weight: 219.283
• Mol File: 126402-81-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate(126402-81-1)
• EPA Substance Registry System: isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate(126402-81-1)

Safety Data

• Hazardous Substances Data: 126402-81-1(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 39613-92-8 alanine isopropyl ester hydrochloride 
• 39825-33-7 isopropyl ester of alanine 
• 120328-90-7 methyl (E)-N-benzylidenealaninate 

Downstream Products

• 1132-26-9 2-methyl-3-phenylalanine 
• 17350-84-4 (R)-2-amino-2-methyl-3-phenylpropanoic acid 
• 23239-35-2 (S)-2-amino-2-methyl-3-phenylpropanoic acid 
• 14603-95-3 2-amino-2-methyl-3-phenylpropanoic acid hydrochloride 
• 96886-56-5 C^α-methyl-D-allylglycine 
• 96886-55-4 (S)-α-allylalanine 
• 14603-77-1 (R)-α-methyl-phenylalanine hydrochloride 
• 130855-57-1 (2S)-2-amino-3-(4-fluorophenyl)-2-methylpropanoic acid 
• 422568-68-1 (R)-α-methyl-para-fluorophenylalanine 

Relevant articles and documents

Metal-dependent stereochemistry of C - C bond formation under the asymmetric phase transfer catalysis by chiral salen complexes

The effect of the nature of the central metal atom in chiral salen type complexes on the stereodifferentiating capacity of these complexes as catalysts in phase transfer asymmetric alkylation of Schiff's base derived from alanine isopropyl ester and benzaldehyde by benzyl bromide. The nature of the central metal atom in the complex has a pronounced influence on the stereochemistry of alkylation; copper(II) complexes exhibit the highest activity combined with a high stereoselectivity.

NOVEL CRYSTAL MODIFICATIONS

Novel crystal modifications of (5S)-5-[4-(5-chloro-pyridin-2-yloxy)-piperidine-1-sulfonylmethyl]-5-methyl-imidazolidine-2,4-dione are disclosed together with processes for preparing such modifications, pharmaceutical compositions comprising such a modification, and the use of such a modification in therapy.

Chiral salen-metal complexes as novel catalysts for the asymmetric synthesis of α-amino acids under phase transfer catalysis conditions

Chiral salen-metal complexes have been tested as catalysts for the C-alkylation of Schiff's bases of alanine and glycine esters with alkyl bromides under phase-transfer conditions (solid sodium hydroxide, toluene, ambient temperature, 1-10 mol% of the catalyst). The best catalyst, which was derived from a Cu(II) complex of (1R, 2R or 1S,2S)-[N,N′-bis(2′-hydroxybenzylidene)]-1,2-diaminocyclohexane, gave α-amino and α-methyl-α-amino acids with enantiomeric excesses of 70-96%.