- SUBSTITUTED 1,2,4-OXADIAZOLE, ITS APPLICATION AND A PHARMACEUTICAL PREPARATION COMPRISING IT
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Substances effective against tuberculosis based on substituted 1,2,4-oxadiazoles of general formula I, where Y = S or CH2 and R = phenyl- or phenyl- substituted in positions 2, 3, 4, and 5 by one or several electron-acceptor groups or electron-donor groups. These compounds can be produced by easy syntheses and are characterized by low toxicity and high efficacy against mycobacteria, including multiresistant strains thereof. The invention also discloses a pharmaceutical preparation containing substituted 1,2,4-oxadiazole of formula I as active substance as well as the use of this substituted 1,2,4-oxadiazole as an antituberculosis drug.
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Page/Page column 11-14
(2020/07/14)
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