- THERAPEUTIC FLUOROETHYL UREAS
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Compounds of the formula or a pharmaceutically acceptable salt thereof or a tautomer thereof, wherein A and B are as described herein, are useful for treating conditions afflicting mammals.
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Page/Page column 17
(2008/06/13)
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- A new asymmetric synthesis of (S)-dolaphenine and its heteroaromatic congeners utilizing (+)-2-hydroxy-3-pinanone and (-)-3-hydroxy-2-caranone as chiral auxiliaries
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(+)-2-hydroxy-3-pinanone ((+)-HyPN,(+)-2a) and (-)-3-hydroxy-2-caranone ((-)-2b) were respectively converted to the corresponding Schiff bases 18a and 18b with 1-(2-thiazolyl)methylamine (17). Alkylation followed by removal of the chiral auxiliaries (+)-2a and (-)-2b afforded (S)-dolaphenine (10) as an optically pure form. The method was applied to the asymmetric synthesis of the dolaphenine analogs 27a-d.
- Irako, Naoko,Hamada, Yasumasa,Shioiri, Takayuki
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p. 12731 - 12744
(2007/10/02)
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- 1-(2-Thienyl)-2-phenylethylamines as potential non-stimulant anorectics
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A series of 1-(2-thienyl)-2-phenylethylamines was synthesized and tested for anorectic and motor activity effects in rats. Phenyl ring substituents included Cl, Br, F, CF3, CH3, OCH3, and NO2; amino group substi
- Mrongovius,Ghosh,Bolt,Ternai
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p. 1718 - 1720
(2007/10/02)
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