42291-11-2

Upstream product

• 13196-28-6 2-phenyl-1-(thiophen-2-yl)ethan-1-one 
• 540-69-2 ammonium formate 
• 6921-34-2 benzylmagnesium chloride 
• 27757-85-3 2-Aminomethylthiophene 

Downstream Products

• 80154-65-0 N-isopropyl-1-(2-thienyl)-2-phenylethylamine hydrochloride 

Relevant academic research and scientific papers

THERAPEUTIC FLUOROETHYL UREAS

Compounds of the formula or a pharmaceutically acceptable salt thereof or a tautomer thereof, wherein A and B are as described herein, are useful for treating conditions afflicting mammals.

A new asymmetric synthesis of (S)-dolaphenine and its heteroaromatic congeners utilizing (+)-2-hydroxy-3-pinanone and (-)-3-hydroxy-2-caranone as chiral auxiliaries

(+)-2-hydroxy-3-pinanone ((+)-HyPN,(+)-2a) and (-)-3-hydroxy-2-caranone ((-)-2b) were respectively converted to the corresponding Schiff bases 18a and 18b with 1-(2-thiazolyl)methylamine (17). Alkylation followed by removal of the chiral auxiliaries (+)-2a and (-)-2b afforded (S)-dolaphenine (10) as an optically pure form. The method was applied to the asymmetric synthesis of the dolaphenine analogs 27a-d.

1-(2-Thienyl)-2-phenylethylamines as potential non-stimulant anorectics

A series of 1-(2-thienyl)-2-phenylethylamines was synthesized and tested for anorectic and motor activity effects in rats. Phenyl ring substituents included Cl, Br, F, CF3, CH3, OCH3, and NO2; amino group substi