- Process method for preparing 5, 6-dimethoxy-1, 2-indanedione
-
The invention discloses a process method for preparing 5, 6-dimethoxy-1, 2-indandione, which comprises the following step: reacting veratrole as a raw material with a hydroxypyruvic acid compound under the action of a catalyst to obtain the 5, 6-dimethoxy-1, 2-indandione. The method has the advantages of short route, short reaction time, simple operation and high yield.
- -
-
Paragraph 0042-0050
(2020/07/21)
-
- Synthesis and biological evaluation of 9-oxo-9hindeno[1,2-b]pyrazine-2,3- dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes
-
High-throughput screening highlighted 9-oxo-9H-indeno[1,2-b]pyrazine-2,3- dicarbonitrile (1) as an active inhibitor of ubiquitin-specific proteases (USPs), a family of hydrolytic enzymes involved in the removal of ubiquitin from protein substrates. The chemical behavior of compound 1 was examined. Moreover, the synthesis and in vitro evaluation of new compounds, analogues of 1, led to the identification of potent and selective inhibitors of the deubiquitinating enzyme USP8.
- Colombo, Matteo,Vallese, Stefania,Peretto, Ilaria,Jacq, Xavier,Rain, Jean-Christophe,Colland, Frederic,Guedat, Philippe
-
experimental part
p. 552 - 558
(2010/12/25)
-
- Novel cysteine protease inhibitors and their therapeutic applications
-
The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.
- -
-
Page/Page column 25
(2008/06/13)
-
- Novel cysteine protease inhibitors and their therapeutic applications
-
The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.
- -
-
Page/Page column 17
(2008/06/13)
-
- A convenient synthesis of xyridin A metabolite from Xyris indica L.
-
A convenient synthesis of xyridin A (isocoumarin) isolated from Xyris indica L. has been carried out, 4,5-Dimethoxyhomophthalic acid is condensed with butanoyl chloride to yield 3-n-propyl-6,7-dimethoxyisocoumarin which on demethylation with aluminium chl
- Ahmed, Hafiz Badar-Ud-Din,Rama, Nasim Hasan,Malana, Muhammad Aslam,Qadeer, Ghulam
-
p. 820 - 822
(2007/10/03)
-
- Investigations of the reaction mechanisms of 1,2-indanediones with amino acids
-
The reaction mechanisms of amino acids with a new class of fluorogenic reagents were investigated. The structures of colored and fluorescent species formed in these reactions were partially confirmed by experimental evidence. Reaction intermediates, C-N-C 1,3-dipoles derived from imines, were trapped with dipolarophiles in 3 + 2 cycloadditions to form spiropyrrolidines.
- Petrovskaia,Taylor,Hauze,Carroll,Joullie
-
p. 7666 - 7675
(2007/10/03)
-