42337-64-4

Usage

Chemical Properties

Orange powder

Upstream product

• 2107-69-9 5,6-dimethoxy-1-indanone 
• 91-16-7 1,2-dimethoxybenzene 
• 534-07-6 1,3-Dichloroacetone 
• 1113-60-6 3-hydroxy-2-oxopropionic acid 
• 203922-38-7 (5,6-Dimethoxy-3H-inden-1-yloxy)-trimethyl-silane 
• 844478-11-1 2-nitroso-5,6-dimethoxyindan-1-one 
• 2107-85-9 5,6-dimethoxy-indan-1,2-dione-2-oxime 
• 2107-73-5 5,6-dimethoxy-2-hydroxy-1-indanone 

Downstream Products

• 3809-00-5 4,5-dimethoxyhomophthalic acid 

Relevant academic research and scientific papers

Process method for preparing 5, 6-dimethoxy-1, 2-indanedione

The invention discloses a process method for preparing 5, 6-dimethoxy-1, 2-indandione, which comprises the following step: reacting veratrole as a raw material with a hydroxypyruvic acid compound under the action of a catalyst to obtain the 5, 6-dimethoxy-1, 2-indandione. The method has the advantages of short route, short reaction time, simple operation and high yield.

Synthesis and biological evaluation of 9-oxo-9hindeno[1,2-b]pyrazine-2,3- dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes

High-throughput screening highlighted 9-oxo-9H-indeno[1,2-b]pyrazine-2,3- dicarbonitrile (1) as an active inhibitor of ubiquitin-specific proteases (USPs), a family of hydrolytic enzymes involved in the removal of ubiquitin from protein substrates. The chemical behavior of compound 1 was examined. Moreover, the synthesis and in vitro evaluation of new compounds, analogues of 1, led to the identification of potent and selective inhibitors of the deubiquitinating enzyme USP8.

Novel cysteine protease inhibitors and their therapeutic applications

The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.

Novel cysteine protease inhibitors and their therapeutic applications

The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.

A convenient synthesis of xyridin A metabolite from Xyris indica L.

A convenient synthesis of xyridin A (isocoumarin) isolated from Xyris indica L. has been carried out, 4,5-Dimethoxyhomophthalic acid is condensed with butanoyl chloride to yield 3-n-propyl-6,7-dimethoxyisocoumarin which on demethylation with aluminium chl

Investigations of the reaction mechanisms of 1,2-indanediones with amino acids

The reaction mechanisms of amino acids with a new class of fluorogenic reagents were investigated. The structures of colored and fluorescent species formed in these reactions were partially confirmed by experimental evidence. Reaction intermediates, C-N-C 1,3-dipoles derived from imines, were trapped with dipolarophiles in 3 + 2 cycloadditions to form spiropyrrolidines.