- Pyrimidine derivatives, and preparation method and use thereof
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Pyrimidine derivatives disclosed in the invention respectively contain an aromatic five-membered heterocycle, a lone electron pair on a hetero atom S, O or N and an unsaturated five-membered ring form a conjugated system, and the lone electron pair effect of above hetero atoms has an inhibition effect on vascular endothelial growth factor (VEGF) receptors VEGFR-1, VEGFR-2 and VEGFR-3, so the pyrimidine derivatives are very good kinase inhibitors. The pyrimidine derivatives have stronger VEGFR-1, VEGFR-2 and VEGFR-3 inhibition activity than pazopanib in the prior art, and can be used treat VEGF signal pathway inhibition diseases, such as lung cancer, kidney cell cancer and other solid tumors.
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Paragraph 0108; 0109; 0110; 0111; 0112
(2016/10/08)
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