423768-49-4

Basic information

• Product Name: 1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE
• Synonyms: BUTTPARK 97\18-52;1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE;1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride 97%;1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonylchloride97%
• CAS NO: 423768-49-4
• Molecular Formula: C₁₁H₈ClFN₂O
• Molecular Weight: 238.65
• Mol File: 423768-49-4.mol

Chemical Properties

• Melting Point: 90-92°C
• Boiling Point: 324.7°C at 760 mmHg
• Flash Point: 150.2°C
• Appearance: /
• Density: 1.473g/cm³
• Vapor Pressure: 0.000242mmHg at 25°C
• Refractive Index: 1.57
• PKA: -2.97±0.10(Predicted)
• CAS DataBase Reference: 1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE(423768-49-4)
• EPA Substance Registry System: 1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE(423768-49-4)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• Hazardous Substances Data: 423768-49-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-fluorophenyl)-5-methyl-1h-pyrazole-4-carbonyl chloride is used as a synthetic intermediate for the production of pharmaceuticals. Its unique structure allows for the creation of a variety of drug molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(4-fluorophenyl)-5-methyl-1h-pyrazole-4-carbonyl chloride serves as a key intermediate in the synthesis of agrochemicals. Its incorporation into these compounds can contribute to the development of effective pesticides or herbicides.
Used in Specialty Chemicals Industry:
1-(4-fluorophenyl)-5-methyl-1h-pyrazole-4-carbonyl chloride is also utilized in the synthesis of specialty chemicals, where its specific properties can be leveraged to create compounds with unique applications in various industrial processes.

InChI:InChI=1/C9H6F3N3S/c10-9(11,12)6-3-1-5(2-4-6)7-8(13)16-15-14-7/h1-4H,13H2

Upstream product

• 217073-76-2 1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid 
• 288252-73-3 ethyl 1-(4-fluorophenyl)-5-methylpyrazole-4-carboxylate 
• 3788-94-1 2-ethoxymethylene-3-oxobutanoic acid ethyl ester 
• 371-14-2 4-fluorophenylhydrazine 

Downstream Products

• 288250-07-7 ethyl 1-{2-cyano-4-[1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide]phenyl}piperidine-4-carboxylate 
• 288250-72-6 N-(3-cyano-4-pyrrolidinophenyl)-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-74-8 N-(3-cyano-4-homopiperidinophenyl)-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288249-88-7 N-[3-cyano-4-(4-hydroxypiperidin-1-yl)phenyl]-N-[1-(4-fluorophenyl)-5-methylpyrazol-4-ylcarbonyl]glycine 
• 288250-08-8 1-{2-cyano-4-[1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide]phenyl}piperidine-4-carboxylic acid 
• 288251-21-8 N-{3-cyano-4-[4-(2-hydroxyethyl)piperidin-1-yl]phenyl}-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 
• 288250-71-5 N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-1-(4-fluorophenyl)-5-methylpyrazole-4-carboxamide 

Relevant articles and documents

AMIDOPYRIDINE DERIVATIVE, AND USE THEREOF

The present invention relates to novel amidopyridine derivatives. More specifically, the present invention provides a medicinal agent which is useful as a prophylactic or therapeutic agent for diseases based on the production of cytokines from T cells, comprising as the active ingredient an amidopyridine derivative or a pharmacologically acceptable salt thereof. Provided are an amidopyridine derivative of the following general formula (I): wherein each symbol has the same meaning as defined in the description, or a pharmacologically acceptable salt thereof.

AMIDE COMPOUNDS AND MEDICINAL USE THEREOF

The present invention relates to a compound of the formula wherein R1 is substituted aryl, heteroaryl and the like, R2 and R3 are hydrogen, alkyl, halogen, hydroxyl group and the like, Q is N, CH and the like, W is hydrogen, alkyl, hydroxycarbonylalkyl and the like, X is halogen, cyano, nitro, amino and the like, X' is hydrogen, halogen, cyano, nitro, and Y is alkyl, hydroxyl group, alkoxy, mercapto and the like and a salt thereof, and a medicine containing the said compound. The compound of the present invention shows a superior inhibitory effect on activated lymphocytes proliferation and is useful as an agent for the prophylaxis or treatment of various autoimmune diseases.