1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride

Base Information

Chemical Name:1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride
CAS No.:423768-49-4
Molecular Formula:C11H8ClFN2O
Molecular Weight:238.64500
Hs Code.:2933199090
DSSTox Substance ID:DTXSID60381589
Wikidata:Q82172494
Mol file:423768-49-4.mol

Synonyms:1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride;423768-49-4;1-(4-fluorophenyl)-5-methylpyrazole-4-carbonyl chloride;1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBONYLCHLORIDE;DTXSID60381589;MFCD03659694;PS-10714;FT-0605716;C80084;A825876;J-503310;1-(4-fluorophenyl)-5-methyl-pyrazole-4-carbonyl chloride

Suppliers and Price of 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride 97%
250 mg
$ 106.00

SynQuest Laboratories
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride 97%
1 g
$ 237.00

Crysdot
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonylchloride 97%
1g
$ 414.00

Apolloscientific
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonylchloride 97%
1g
$ 148.00

Apolloscientific
1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonylchloride 97%
250mg
$ 66.00

American Custom Chemicals Corporation
1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE 95.00%
1G
$ 792.89

American Custom Chemicals Corporation
1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE 95.00%
250MG
$ 673.55

Total 11 raw suppliers

Chemical Property of 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride

Chemical Property:

Vapor Pressure:0.000242mmHg at 25°C
Melting Point:90-92oC
Boiling Point:324.7oC at 760 mmHg
PKA:-2.97±0.10(Predicted)
Flash Point:150.2oC
PSA：34.89000
Density:1.473g/cm3
LogP:2.69880
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:238.0309187
Heavy Atom Count:16
Complexity:269

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:C
Statements: 34
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=NN1C2=CC=C(C=C2)F)C(=O)Cl

Technology Process of 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride

There total 5 articles about 1-(4-Fluorophenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 217073-76-2
1-(4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

: 423768-49-4
1-(4-Fluoro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride

Guidance literature:: With thionyl chloride; In 1,2-dichloro-ethane; at 83 ℃; for 0.5h;

Reference yield:

: 288252-73-3
ethyl 1-(4-fluorophenyl)-5-methylpyrazole-4-carboxylate

: 423768-49-4
1-(4-Fluoro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 2 h / Heating / reflux

2: thionyl chloride / 1,2-dichloro-ethane / 0.5 h / 83 °C

With sodium hydroxide; thionyl chloride; In ethanol; water; 1,2-dichloro-ethane;

Reference yield:

: 371-14-2
4-fluorophenylhydrazine

: 423768-49-4
1-(4-Fluoro-phenyl)-5-methyl-1H-pyrazole-4-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 2 h / Heating / reflux

2: sodium hydroxide / ethanol; water / 2 h / Heating / reflux

3: thionyl chloride / 1,2-dichloro-ethane / 0.5 h / 83 °C

With sodium hydroxide; thionyl chloride; In ethanol; water; 1,2-dichloro-ethane;