42403-77-0

Basic information

• Product Name: phenyl[4-(prop-2-en-1-yloxy)phenyl]methanone
• Synonyms: [4-(Allyloxy)phenyl](phenyl)methanone; 4-Allyloxybenzophenone; methanone, phenyl[4-(2-propen-1-yloxy)phenyl]-
• CAS NO: 42403-77-0
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.2812
• Mol File: 42403-77-0.mol

Chemical Properties

• Boiling Point: 379.3°C at 760 mmHg
• Flash Point: 168.6°C
• Density: 1.084g/cm³
• Vapor Pressure: 5.89E-06mmHg at 25°C
• Refractive Index: 1.566
• CAS DataBase Reference: phenyl[4-(prop-2-en-1-yloxy)phenyl]methanone(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl[4-(prop-2-en-1-yloxy)phenyl]methanone(42403-77-0)
• EPA Substance Registry System: phenyl[4-(prop-2-en-1-yloxy)phenyl]methanone(42403-77-0)

Safety Data

• Hazardous Substances Data: 42403-77-0(Hazardous Substances Data)

Upstream product

• 106-95-6 allyl bromide 
• 1137-42-4 4-Hydroxybenzophenone 
• 36844-51-6 4-allyloxybenzoyl chloride 
• 100-58-3 phenylmagnesium bromide 
• 26595-60-8 allyl (4-allyloxy)benzoate 
• 27914-60-9 4-allyloxybenzoic acid 
• 99-96-7 4-hydroxy-benzoic acid 

Downstream Products

• 73720-75-9 (3-allyl-4-hydroxyphenyl)(phenyl)methanone 
• 610757-15-8 4-(3'-triethoxysilyl)propyloxybenzophenone 
• 112004-94-1 3-allyl-4-(pivaloyloxy)benzophenone 
• 112005-13-7 3-(2-carboxyethyl)-4-(pivaloyloxy)benzophenone 
• 112004-96-3 3-(3-hydroxypropyl)-4-(pivaloyloxy)benzophenone 
• 114031-93-5 3-(2-hydroxy-5-benzoylphenyl)propionic acid 
• 114031-68-4 6-benzoyl-3,4-dihydro-2H-1-benzopyran-2-one 
• 183013-63-0 4-(4-Benzoyl-2-propyl-phenoxymethyl)-benzaldehyde 
• 183013-50-5 (4-hydroxy-3-propyl-phenyl)-phenyl-methanone 

Relevant articles and documents

Photochemical attachment of polymer films to solid surfaces via monolayers of benzophenone derivatives

We report a simple and yet effective way to photochemically attach thin polymeric layers to solid surfaces. The system is based on a photoreactive benzophenone derivative that is bound to SiO2 surfaces via a silane anchor. This substrate is the

Fe-S Catalyst Generated in Situ from Fe(III)- And S3?--Promoted Aerobic Oxidation of Terminal Alkenes

An iron-sulfur complex formed by the simple mixture of FeCl3 with S3?- generated in situ from K2S is developed and applied to selective aerobic oxidation of terminal alkenes. The reaction was carried out under an atmosphere of O2 (balloon) and could proceed on a gram scale, expanding the application of S3?- in organic synthesis. This study also encourages us to explore the application of an Fe-S catalyst in organic reactions.

Enantioselective Synthesis of 3-Fluorochromanes via Iodine(I)/Iodine(III) Catalysis

The chromane nucleus is common to a plenum of bioactive small molecules where it is frequently oxidized at position 3. Motivated by the importance of this position in conferring efficacy, and the prominence of bioisosterism in drug discovery, an iodine(I)/iodine(III) catalysis strategy to access enantioenriched 3-fluorochromanes is disclosed (up to 7:93 e.r.). In situ generation of ArIF2 enables the direct fluorocyclization of allyl phenyl ethers to generate novel scaffolds that manifest the stereoelectronic gauche effect. Mechanistic interrogation using deuterated probes confirms a stereospecific process consistent with a type IIinv pathway.

Benzophenone type derivative photoinitiator and preparation method thereof

The invention belongs to the field of photosensitive high polymer materials. After a hydrogen abstraction type photoinitiator absorbs light energy, the photoinitiator produces a bimolecular action with an auxiliary initiator in an excited state to generat

An atom-economical and stereoselective domino synthesis of functionalised dienes

Open sesame: A direct synthesis of functionalised and stereodefined dienes, relying on a domino allylic alkylation/electrocyclic ring-opening sequence, is reported. This method allows concise access to doubly vinylogous esters. A further systematic study

Polymeric photoinitiators

UV curable compositions, polymeric photoinitiators and precursors therefor are described.

Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)

As a continuation of our project aimed at the search for new chemotherapeutic agents against Chagas' disease, several drugs structurally related to the insect growth regulator Fenoxycarb and the naturally occurring juvenfie hormone of insects were designed, synthesized, and evaluated as antiproliferative agents against the parasite responsible of this disease. Isoprenoid derivatives (compounds 33, 34, 36, and 37) were potent growth inhibitors of Trypanosoma cruzi epimastigotes. In addition, taking into account the high activity observed for compound 30 and the inhibitory action of related compounds, the allyl ether moiety bonded at the polar extreme of these inhibitors proved to be a promising group for the design of new drugs.

Synthesis and structure-activity relationships of benzophenones as inhibitors of cathepsin D

Non peptide inhibitors of cathepsin D, an aspartyl protease that has been implicated in many disease states including Alzheimer's disease, were prepared and evaluated. The most potent inhibitor of cathepsin D in this series was found to be (Z)-5-[[4-(4-be

(Acyloxy)benzophenones and (Acyloxy)-4-pyrones. A New Class of Inhibitors of Human Neutrophil Elastase

A series of 4-(acyloxy)- and 4,4'-bis(acyloxy)benzophenones were synthesized.Some of them, pivalates (trimethylacetates) and isobutyrates in particular, were found to be potent and selective inhibitors of human neutrophil (leukocyte) elastase.A series of 2--5-(acyloxy)-4-pyrones were synthesized regioselectively from kojic acid.The 4-pyrones bearing a long chain acyl group at the 2-position and either pivaloyloxy or isobutyryloxy at the 5-position were potent and selective inhibitors of the human elastase.A number of analogues and derivatives in both series were synthesized in order to study the structure-activity relationship as summarized in Tables I-VI and in Tables IX and X.The inhibition was selective to human neutrophil elastase.No inhibition of porcine pancreatic elastase or bovine pancreatic chymotrypsin (Tables VII and XI) was observed.The most likely mechanism of inhibition is discussed.The implication of these findings for the treatment of rheumatoid arthritis and emphysema is outlined.