- Intramolecular Friedel-Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol
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Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.
- Motiwala, Hashim F.,Vekariya, Rakesh H.,Aubé, Jeffrey
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p. 5484 - 5487
(2015/11/18)
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- Tricyclic polyhydroxylic tyrosine kinase inhibitors
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Certain tricyclic polyhydroxylic compounds, and their pharmaceutically-acceptable salts, are inhibitors of tyrosine kinase enzymes, and so are useful for the control of tyrosine kinase dependent diseases (e.g., cancer, atherosclerosis).
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- An efficient synthesis of dihydroxyfluorenones via in situ Pd(0)-catalyzed cross-coupling
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All six dimethoxyfluorenones 6a-f and dihydroxyfluorenones 7a-f, wherein substitution occurs at only one aromatic ring, were conveniently prepared by palladium(0)-catalyzed cross-coupling reactions of aryl bromides/triflates 2a-e with in situ generated ar
- Ciske, Fred L.,Jones Jr., Winton D.
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p. 1195 - 1198
(2007/10/03)
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- Reaction of 1,2-Dimethoxybiphenylene with Dichlorocarbene. Chemical Detection of the Bond Fixation in Biphenylene Derivatives
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1,2-Dimethoxybiphenylene reacted with dichlorocarbene to give three chloro(methoxy)-6H-benzo-cyclobutacyclohepten-6-one derivatives, two chloro(methoxy)fluorenones and two dimethoxyfluorenones.The reaction with dibromocarbene gave similar products.The formation of these products serves an unequivocal chemical evidence for bond fixation of 1,2-dimethoxybiphenylene.The chloro(methoxy)-6H-benzocyclobutacyclohepten-6-one was led to 9-chloro-5-hydroxy-6H-benzocyclobutacyclohepten-6-one, the first tropolone analogue of biphenylene.This compound was shown to exist in only one of the two possible tautomers in contrast with general monocyclic tropolones.
- Sato, Masaru,Inaba, Keiko,Ebine, Seiji,Tsunetsugu, Josuke
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p. 2334 - 2339
(2007/10/02)
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- Study of Electrochromism of Methoxyfluorene Compounds
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The electrochemical and electrochromic properties of a variety of polysubstituted fluorene compounds have been studied.The 2,7- and 2,3-dimethoxy, 2,3,6,7-tetramethoxy, and 2,3,4,5,6,7-hexamethoxyfluorenes are highly reversible electrochromic materials.One-electron oxidation of these materials yields deeply colored, stable radical cations.The structure-property relationships observed for the electrochemical and absorption behavior of these materials are discussed.
- Grant, Barbara,Clecak, N. J.,Oxsen, Michael
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p. 702 - 705
(2007/10/02)
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