Cu(I)-catalyzed intramolecular cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions
Novel, easy-to-perform and practical intramolecular Cu(I)-catalyzed cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions are reported. The isolated cyclized products under microwave conditions are obtained with high yields and with short reaction times offering a valuable and reliable alternative to other protocols for the synthesis of fluorene analogues.
Haggam, Reda A.
p. 6488 - 6494
(2013/07/26)
Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs
Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions. Achieving DNA cleavage under these reducing conditions is key to anticancer activity, as the most active compound, 1-methoxydiazofluorene, inhibits the proliferation of HeLa cells.
Zeng, Wei,Eric Ballard,Tkachenko, Alexander G.,Burns, Virginia A.,Feldheim, Daniel L.,Melander, Christian
p. 5148 - 5151
(2007/10/03)
An efficient synthesis of dihydroxyfluorenones via in situ Pd(0)-catalyzed cross-coupling
All six dimethoxyfluorenones 6a-f and dihydroxyfluorenones 7a-f, wherein substitution occurs at only one aromatic ring, were conveniently prepared by palladium(0)-catalyzed cross-coupling reactions of aryl bromides/triflates 2a-e with in situ generated ar
Ciske, Fred L.,Jones Jr., Winton D.
p. 1195 - 1198
(2007/10/03)
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