42523-22-8

Upstream product

• 87-25-2 2-ethoxycarbonylaniline 
• 150-78-7 1,4-dimethoxybezene 
• 3701-38-0 2-Methoxy-6H-dibenzopyran-6-one 
• 3525-23-3 2',5'-dimethoxy-biphenyl-2-carboxylic acid 
• 213479-72-2 2',5'-Dimethoxy-biphenyl-2-carboxylic acid diethylamide 
• 76041-86-6 2-bromo-N,N-diethylbenzamide 
• 25245-34-5 1-bromo-2,5-dimethoxybenzene 
• 88-67-5 2-Iodobenzoic acid 
• 24061-14-1 1,4-dimethoxy-9H-fluoren-9-one 

Downstream Products

• 43074-35-7 9-oxo-1,4-bis(phenyl)fluorene 
• 78237-28-2 1,4-Di-p-tolyl-fluoren-9-one 
• 78237-29-3 1,4-bis(4-methoxyphenyl)-9H-fluoren-9-one 

Relevant academic research and scientific papers

Cu(I)-catalyzed intramolecular cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions

Novel, easy-to-perform and practical intramolecular Cu(I)-catalyzed cyclizations of substituted 2-iodobenzophenones under thermal and microwave conditions are reported. The isolated cyclized products under microwave conditions are obtained with high yields and with short reaction times offering a valuable and reliable alternative to other protocols for the synthesis of fluorene analogues.

Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs

Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions. Achieving DNA cleavage under these reducing conditions is key to anticancer activity, as the most active compound, 1-methoxydiazofluorene, inhibits the proliferation of HeLa cells.

An efficient synthesis of dihydroxyfluorenones via in situ Pd(0)-catalyzed cross-coupling

All six dimethoxyfluorenones 6a-f and dihydroxyfluorenones 7a-f, wherein substitution occurs at only one aromatic ring, were conveniently prepared by palladium(0)-catalyzed cross-coupling reactions of aryl bromides/triflates 2a-e with in situ generated ar