- A direct cycloaminative approach to imidazole derivatives via dual C-H functionalization
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Organoiodine(III)-promoted C(sp3)-H azidation was a key step for the cycloaminative process. An unprecedented method for metal-free dehydrogenative N-incorporation into C(sp3)-H and C(sp2)-H bonds for the synthesis of diverse imidazoles has been disclosed. The overall transformation involves the construction of four C-N bonds through hydroamination-azidation-cyclization sequence. The reaction can be easily handled and proceeds under mild conditions. Further, the potential of the present strategy is revealed by the practical synthesis of N-heterocyclic carbene (NHC) precursors.
- Arepally, Sagar,Babu, Venkata Nagarjuna,Bakthadoss, Manickam,Sharada, Duddu S.
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supporting information
p. 5014 - 5017
(2017/11/06)
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- PDE10 MODULATORS
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The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used in the treatment of CNS disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease.
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Paragraph 0207
(2013/03/26)
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- PDE10 MODULATORS
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The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.
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Page/Page column 33; 35
(2013/03/26)
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- A new generation of aprotic yet Bronsted acidic imidazolium salts: Low toxicity, high recyclability and greatly improved activity
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Catalysts which have low antimicrobial toxicity and are aprotic, yet which can act as Bronsted acidic catalysts in the presence of protic additives have been developed. The catalysts are recyclable, considerably more active (i.e. can be used at 10-50 times lower loadings) and of broader scope than their antecedent generation.
- Myles, Lauren,Gore, Rohitkumar G.,Gathergood, Nicholas,Connon, Stephen J.
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supporting information
p. 2740 - 2746
(2013/10/08)
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- 1-ALKYL- AND 1-GLUCOSYL-4,5-IMIDAZOLEDICARBOXAMIDES
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Among 4,5-imidazoledicarboxamides compounds were found which possess clearly defined neurotropic activity.In order to study the relation between the structure and the activity a series a new 4,5-imidazoledicarboxamides substituted in the amide groups and at the nitrogen of the imidazole ring were obtained.Their syntheses and characteristics are described.
- Aleksandrova, I. Ya.,Khrustaleva, V. S.,Khromov-Borisov, N. V.
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p. 364 - 367
(2007/10/02)
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