42545-22-2

Usage

Uses

Used in Pharmaceutical Industry:
1-Methyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester is used as a building block for the synthesis of various pharmaceutical and biologically active compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Drug Discovery:
1-Methyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester is utilized in the research and development of new drugs, contributing to the advancement of pharmaceutical treatments and therapies. Its role in drug discovery is crucial for identifying and creating novel therapeutic agents.
Used in Organic Chemistry:
1-Methyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester serves as a reactant in the production of other chemical compounds, further expanding its applications in the field of organic chemistry.
Used in the Preparation of Organic Intermediates:
1-Methyl-1H-imidazole-4,5-dicarboxylic acid dimethyl ester is also employed in the preparation of organic intermediates, which are essential for the synthesis of a wide range of chemical products, including pharmaceuticals, agrochemicals, and other specialty chemicals.

Upstream product

• 408351-07-5 1-methyl-2-thioxo-2,3-dihydro-1H-imidazole-4,5-dicarboxylic acid dimethyl ester 
• 3304-70-9 dimethyl imidazole-4,5-dicarboxylate 
• 74-88-4 methyl iodide 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 67751-25-1 1-dimethylamino-1,2-di(methoxycarbonyl)ethene 
• 570-22-9 4,5-imidazoledicarboxylic acid 

Downstream Products

• 42190-84-1 1-methyl-4,5-imidazoledicarbonyl chloride 
• 86281-16-5 N,N-dicyclohexyl-1-methyl-4,5-imidazoledicarboxamide 
• 81609-12-3 1,2,3,6-tetrahydro-1,2,7-trimethylimidazo-3,6-pyridazinedione 
• 19485-38-2 1-methyl-1H-imidazole-4,5-dicarboxylic acid 

Relevant academic research and scientific papers

A direct cycloaminative approach to imidazole derivatives via dual C-H functionalization

Organoiodine(III)-promoted C(sp3)-H azidation was a key step for the cycloaminative process. An unprecedented method for metal-free dehydrogenative N-incorporation into C(sp3)-H and C(sp2)-H bonds for the synthesis of diverse imidazoles has been disclosed. The overall transformation involves the construction of four C-N bonds through hydroamination-azidation-cyclization sequence. The reaction can be easily handled and proceeds under mild conditions. Further, the potential of the present strategy is revealed by the practical synthesis of N-heterocyclic carbene (NHC) precursors.

PDE10 MODULATORS

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used in the treatment of CNS disorders such as schizophrenia, Alzheimer's disease, and Parkinson's disease.

PDE10 MODULATORS

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R5, W, X, X1, Y, Y1, Z and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit PDE10A and can be used as medicaments.

A new generation of aprotic yet Bronsted acidic imidazolium salts: Low toxicity, high recyclability and greatly improved activity

Catalysts which have low antimicrobial toxicity and are aprotic, yet which can act as Bronsted acidic catalysts in the presence of protic additives have been developed. The catalysts are recyclable, considerably more active (i.e. can be used at 10-50 times lower loadings) and of broader scope than their antecedent generation.

1-ALKYL- AND 1-GLUCOSYL-4,5-IMIDAZOLEDICARBOXAMIDES

Among 4,5-imidazoledicarboxamides compounds were found which possess clearly defined neurotropic activity.In order to study the relation between the structure and the activity a series a new 4,5-imidazoledicarboxamides substituted in the amide groups and at the nitrogen of the imidazole ring were obtained.Their syntheses and characteristics are described.