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2-amino-5-iodo-3-pyridinylamine, also known as 5-Amino-2-iodopyridine, is a chemical compound characterized by a pyridine ring with an amino group at the 5-position and an iodine atom at the 2-position. It serves as a vital building block in organic synthesis and is widely recognized for its applications in the pharmaceutical industry, particularly in the development of various drugs. Its distinctive structural features and functional groups make it a valuable component in medicinal chemistry and drug discovery processes.

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  • 426463-01-6 Structure
  • Basic information

    1. Product Name: 2-amino-5-iodo-3-pyridinylamine
    2. Synonyms: 2-amino-5-iodo-3-pyridinylamine;5-IODOPYRIDINE-2,3-DIAMINE;2,3-PyridinediaMine, 5-iodo-;2,3-Diamino-5-iodopyridine
    3. CAS NO:426463-01-6
    4. Molecular Formula: C5H6IN3
    5. Molecular Weight: 235.03
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 426463-01-6.mol
  • Chemical Properties

    1. Melting Point: 109-111°
    2. Boiling Point: 395.6±42.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 2.150±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 4.79±0.49(Predicted)
    10. CAS DataBase Reference: 2-amino-5-iodo-3-pyridinylamine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-amino-5-iodo-3-pyridinylamine(426463-01-6)
    12. EPA Substance Registry System: 2-amino-5-iodo-3-pyridinylamine(426463-01-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: IRRITANT
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 426463-01-6(Hazardous Substances Data)

426463-01-6 Usage

Uses

Used in Pharmaceutical Industry:
2-amino-5-iodo-3-pyridinylamine is used as a key building block for the synthesis of a variety of pharmaceutical compounds. Its presence in the molecular structure of drugs contributes to their therapeutic properties and efficacy.
Used in Organic Synthesis:
In the field of organic synthesis, 2-amino-5-iodo-3-pyridinylamine is utilized as a versatile reagent for the creation of complex organic compounds. Its unique structure allows for multiple synthetic pathways, enhancing the diversity of chemical products that can be derived from it.
Used in Medicinal Chemistry:
2-amino-5-iodo-3-pyridinylamine is employed as a crucial component in medicinal chemistry, where it is involved in the design and development of new drugs. Its functional groups and structural attributes facilitate targeted drug action and contribute to the optimization of drug candidates for specific therapeutic applications.
Used in Drug Discovery:
In drug discovery, 2-amino-5-iodo-3-pyridinylamine plays a significant role as a starting material or intermediate in the synthesis of potential drug candidates. Its unique chemical properties make it a valuable asset in the search for novel therapeutic agents with improved pharmacological profiles.

Check Digit Verification of cas no

The CAS Registry Mumber 426463-01-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,2,6,4,6 and 3 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 426463-01:
(8*4)+(7*2)+(6*6)+(5*4)+(4*6)+(3*3)+(2*0)+(1*1)=136
136 % 10 = 6
So 426463-01-6 is a valid CAS Registry Number.

426463-01-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-iodopyridine-2,3-diamine

1.2 Other means of identification

Product number -
Other names 5-IODO-2,3-DIAMINOPYRIDINE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:426463-01-6 SDS

426463-01-6Relevant articles and documents

Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis

Ko, Kwangseok,Kim, Hye-Jung,Ho, Pil-Su,Lee, Soon Ok,Lee, Ji-Eun,Min, Cho-Rong,Kim, Yu Chul,Yoon, Ju-Han,Park, Eun-Jung,Kwon, Young-Jin,Yun, Jee-Hun,Yoon, Dong-Oh,Kim, Jung-Sook,Park, Woul-Seong,Oh, Seung-Su,Song, Yu-Mi,Cho, Woon-Ki,Morikawa, Kazumi,Lee, Kyoung-June,Park, Chan-Hee

supporting information, p. 2949 - 2961 (2018/04/23)

The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large number of H4R antagonists have been disclosed, but no efficient agents controlling both pruritus and inflammation in AD have been developed yet. Here, we have discovered a novel class of orally available H4R antagonists showing strong anti-itching and anti-inflammation activity as well as excellent selectivity against off-targets. A pharmacophore-based virtual screening system constructed in-house successfully identified initial hit compound 9, and the subsequent homology model-guided optimization efficiently led us to discover pyrido[2,3-e]tetrazolo[1,5-a]pyrazine analogue 48 as a novel chemotype of a potent and highly selective H4R antagonist. Importantly, orally administered compound 48 exhibits remarkable efficacy on antipruritus and anti-inflammation with a favorable pharmacokinetic (PK) profile in several mouse models of AD. Thus, these data strongly suggest that our compound 48 is a promising clinical candidate for treatment of AD.

NOVEL HETEROCYCLIC DERIVATIVES AND THEIR USES

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Paragraph 0742-0744, (2014/10/29)

The present invention relates to novel heterocyclic compounds useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.

Compounds and methods for promoting smoking cessation

-

, (2008/06/13)

Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.

Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-N-oxide as selective glycine antagonists

Cugola, Alfredo,Donati, Daniele,Guarneri,Micheli, Fabrizio,Missio, Andrea,Pecunioso, Angelo,Reggiani, Angelo,Tarzia,Zanirato

, p. 2749 - 2754 (2007/10/03)

Pyrido[2,3-b]pyrazines and pyrido[2,3-b]pyrazines-N-oxides have been synthesized and evaluated for in vitro/in vivo antagonistic activity at the glycine site on the NMDA receptor.

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