426463-01-6

Basic information

• Product Name: 2-amino-5-iodo-3-pyridinylamine
• Synonyms: 2-amino-5-iodo-3-pyridinylamine;5-IODOPYRIDINE-2,3-DIAMINE;2,3-PyridinediaMine, 5-iodo-;2,3-Diamino-5-iodopyridine
• CAS NO: 426463-01-6
• Molecular Formula: C₅H₆IN₃
• Molecular Weight: 235.03
• Mol File: 426463-01-6.mol

Chemical Properties

• Melting Point: 109-111°
• Boiling Point: 395.6±42.0 °C(Predicted)
• Appearance: /
• Density: 2.150±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.79±0.49(Predicted)
• CAS DataBase Reference: 2-amino-5-iodo-3-pyridinylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-iodo-3-pyridinylamine(426463-01-6)
• EPA Substance Registry System: 2-amino-5-iodo-3-pyridinylamine(426463-01-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 426463-01-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-amino-5-iodo-3-pyridinylamine is used as a key building block for the synthesis of a variety of pharmaceutical compounds. Its presence in the molecular structure of drugs contributes to their therapeutic properties and efficacy.
Used in Organic Synthesis:
In the field of organic synthesis, 2-amino-5-iodo-3-pyridinylamine is utilized as a versatile reagent for the creation of complex organic compounds. Its unique structure allows for multiple synthetic pathways, enhancing the diversity of chemical products that can be derived from it.
Used in Medicinal Chemistry:
2-amino-5-iodo-3-pyridinylamine is employed as a crucial component in medicinal chemistry, where it is involved in the design and development of new drugs. Its functional groups and structural attributes facilitate targeted drug action and contribute to the optimization of drug candidates for specific therapeutic applications.
Used in Drug Discovery:
In drug discovery, 2-amino-5-iodo-3-pyridinylamine plays a significant role as a starting material or intermediate in the synthesis of potential drug candidates. Its unique chemical properties make it a valuable asset in the search for novel therapeutic agents with improved pharmacological profiles.

Upstream product

• 25391-57-5 5-Iodo-3-nitro-2-aminopyridine 

Downstream Products

• 857379-89-6 N-(2-amino-5-iodo-pyridin-3-yl)-3-[4-methyl-6-(trityl-amino)-pyridin-2-yl]-propionamide 

Relevant articles and documents

Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis

The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large number of H4R antagonists have been disclosed, but no efficient agents controlling both pruritus and inflammation in AD have been developed yet. Here, we have discovered a novel class of orally available H4R antagonists showing strong anti-itching and anti-inflammation activity as well as excellent selectivity against off-targets. A pharmacophore-based virtual screening system constructed in-house successfully identified initial hit compound 9, and the subsequent homology model-guided optimization efficiently led us to discover pyrido[2,3-e]tetrazolo[1,5-a]pyrazine analogue 48 as a novel chemotype of a potent and highly selective H4R antagonist. Importantly, orally administered compound 48 exhibits remarkable efficacy on antipruritus and anti-inflammation with a favorable pharmacokinetic (PK) profile in several mouse models of AD. Thus, these data strongly suggest that our compound 48 is a promising clinical candidate for treatment of AD.

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The present invention relates to novel heterocyclic compounds useful in preparing drugs for treatment of diseases associated with various functions of the histamine 4 receptor. Especially, the said drugs are useful for treatment of inflammatory diseases, allergy, pain, nasal polyps, rhinitis, chronic sinusitis, nasal congestion, nasal itch, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, atopic dermatitis, psoriasis, eczema, pruritus, itchy skin, urticaria, idiopathic chronic urticaria, scleroderma, conjunctivitis, keratoconjunctivitis, ocular inflammation, dry eye, cardiac dysfunction, arrhythmia, atherosclerosis, multiple sclerosis, inflammatory bowel disease (including colitis, Crohn's disease, ulcerative colitis), inflammatory pain, neuropathic pain, osteoarthritic pain, autoimmune thyroid disease, immune-mediated (also known as type I) diabetes, lupus, post-operative adhesions, vestibular disorders and cancer.

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