2-amino-5-iodo-3-pyridinylamine

Base Information

• Chemical Name: 2-amino-5-iodo-3-pyridinylamine
• CAS No.: 426463-01-6
• Molecular Formula: C5H6IN3
• Molecular Weight: 235.027
• Hs Code.: 2933399990
• Mol file: 426463-01-6.mol

Synonyms:aminoiodopyridinylamine;2,3-diamino-5-iodopyridine;2,3-Pyridinediamine,5-iodo;2-amino-5-iodo-3-pyridinylamine;5-IODO-2,3-DIAMINOPYRIDINE;

Chemical Property of 2-amino-5-iodo-3-pyridinylamine

Chemical Property:

• Melting Point: 109-111oC
• Boiling Point: 395.6±42.0 °C(Predicted)
• PKA: 4.79±0.49(Predicted)
• PSA: 64.93000
• Density: 2.150±0.06 g/cm3(Predicted)
• LogP: 2.01300
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5-iodo-3-pyridinylamine >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-amino-5-iodo-3-pyridinylamine

There total 1 articles about 2-amino-5-iodo-3-pyridinylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-Iodo-3-nitro-2-aminopyridine (25391-57-5) → 5-iodopyridine-2,3-diamine (426463-01-6)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; at 100 ℃;

Reference yield:

3-(trifluoromethoxy)benzaldehyde (52771-21-8,50823-91-1) + 5-iodopyridine-2,3-diamine (426463-01-6) → 5-iodo-N3-(3-(trifluoromethoxy)benzyl)pyridine-2,3-diamine

Guidance literature:

3-(trifluoromethoxy)benzaldehyde; 5-iodopyridine-2,3-diamine; With acetic acid; In tetrahydrofuran; at 10 - 35 ℃;

With methanol; sodium tetrahydroborate; at 10 - 35 ℃;

Reference yield:

3-[4-methyl-6-(trityl-amino)-pyridin-2-yl]-propionic acid (857379-96-5) + 5-iodopyridine-2,3-diamine (426463-01-6) → N-(2-amino-5-iodo-pyridin-3-yl)-3-[4-methyl-6-(trityl-amino)-pyridin-2-yl]-propionamide (857379-89-6)

Guidance literature:

With O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In pyridine; at 50 ℃; for 24h;

upstream raw materials:

5-Iodo-3-nitro-2-aminopyridine

Downstream raw materials:

N-(2-amino-5-iodo-pyridin-3-yl)-3-[4-methyl-6-(trityl-amino)-pyridin-2-yl]-propionamide

Refernces

• 1、 -. "NOVEL HETEROCYCLIC DERIVATIVES AND THEIR USES". Paragraph 0742-0744. . Retrieved 2014/10/29.
• 2、 Cugola, Alfredo,Donati, Daniele,Guarneri,Micheli, Fabrizio,Missio, Andrea,Pecunioso, Angelo,Reggiani, Angelo,Tarzia,Zanirato. "Synthesis and biological evaluation of pyrido[2,3-b]pyrazine and pyrido[2,3-b]pyrazine-N-oxide as selective glycine antagonists". . p. 2749 - 2754. Retrieved 2007/10/03.