426834-69-7

Basic information

• Product Name: NS 5806
• Synonyms: NS 5806;N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea
• CAS NO: 426834-69-7
• Molecular Formula: C16H8Br2F6N6O
• Molecular Weight: 574.0727392
• Mol File: 426834-69-7.mol

Chemical Properties

• Appearance: white to faint yellow/
• Storage Temp.: 2-8°C
• Solubility: DMSO: >30mg/mL
• CAS DataBase Reference: NS 5806(CAS DataBase Reference)
• NIST Chemistry Reference: NS 5806(426834-69-7)
• EPA Substance Registry System: NS 5806(426834-69-7)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 426834-69-7(Hazardous Substances Data)

Usage

Biochem/physiol Actions

NS5806 increases peak current amplitude of the potassium channel Kv4.3 (EC50 = 5.3 uM). NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. In ventricular cardiomycytes, NS5806 increases transient outward current and reproduces the electrocardiographic profile of Brugada syndrome.

Upstream product

• 68385-95-5 3,5-dibromoanthranilonitrile 
• 1885-29-6 anthranilic acid nitrile 
• 202341-04-6 2,4-dibromo-6-(1H-tetrazol-5-yl)aniline 
• 16588-74-2 3,5-ditrifluoromethylisocyanate 

Relevant articles and documents

FUNCTION CONTROL AGENT FOR PLANT POTASSIUM ION TRANSPORTER, AND METHOD OF GROWING PLANT

PROBLEM TO BE SOLVED: To provide: a function control agent for a plant potassium ion transporter by screening diphenylurea compound derivatives having function control activity targeting a transporter of a plant; and a method of growing a plant body modif

Effect of the Ito activator NS5806 on cloned Kv4 channels depends on the accessory protein KChIP2

BACKGROUND AND PURPOSE The compound NS5806 increases the transient outward current (Ito) in canine ventricular cardiomyocytes and slows current decay. In human and canine ventricle, Ito is thought to be mediated by KV4.3 a