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CAS

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MIDODRINE is an aromatic ether that is 1,4-dimethoxybenzene, substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. It is a direct-acting sympathomimetic with selective alpha-adrenergic agonist activity. MIDODRINE is primarily used as a peripheral vasoconstrictor in the treatment of certain hypotensive states. Its main active component is its major metabolite, deglymidodrine.

42794-76-3

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42794-76-3 Usage

Uses

Used in Pharmaceutical Industry:
MIDODRINE is used as an antihypotensive agent for the treatment of certain hypotensive states. It functions as a peripheral vasoconstrictor, helping to increase blood pressure and improve blood flow in individuals suffering from low blood pressure conditions.
Used in Medical Treatment:
MIDODRINE is used as a therapeutic agent in the management of orthostatic hypotension, a condition where blood pressure drops significantly upon standing. It helps to alleviate symptoms such as dizziness, lightheadedness, and fatigue associated with this condition.
Used in Clinical Settings:
MIDODRINE is utilized in clinical settings to treat patients with symptomatic neurogenic orthostatic hypotension, a condition that results from the dysfunction of the autonomic nervous system. It helps to improve the patient's quality of life by reducing the severity of symptoms and enhancing their ability to perform daily activities.

Check Digit Verification of cas no

The CAS Registry Mumber 42794-76-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,7,9 and 4 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 42794-76:
(7*4)+(6*2)+(5*7)+(4*9)+(3*4)+(2*7)+(1*6)=143
143 % 10 = 3
So 42794-76-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)

42794-76-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name midodrine

1.2 Other means of identification

Product number -
Other names 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:42794-76-3 SDS

42794-76-3Downstream Products

42794-76-3Relevant articles and documents

Organobase-catalyzed amidation of esters with amino alcohols

Caldwell, Nicola,Jamieson, Craig,Simpson, Iain,Tuttle, Tell

supporting information, p. 2506 - 2509 (2013/06/27)

A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.

Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives

Tsuda, Masahiro,Terada, Tomohiro,Irie, Megumi,Katsura, Toshiya,Niida, Ayumu,Tomita, Kenji,Fujii, Nobutaka,Inui, Ken-Ichi

, p. 455 - 460 (2008/01/27)

Midodrine is an oral drug for orthostatic hypotension. This drug is almost completely absorbed after oral administration and converted into its active form, 1-(2′,5′-dimethoxyphenyl)-2-aminoethanol) (DMAE), by the cleavage of a glycine residue. The intestinal H+-coupled peptide transporter 1 (PEPT1) transports various peptide-like drugs and has been used as a target molecule for improving the intestinal absorption of poorly absorbed drugs through amino acid modifications. Because midodrine meets these requirements, we examined whether midodrine can be a substrate for PEPT1. The uptake of midodrine, but not DMAE, was markedly increased in PEPT1-expressing oocytes compared with water-injected oocytes. Midodrine uptake by Caco-2 cells was saturable and was inhibited by various PEPT1 substrates. Midodrine absorption from the rat intestine was very rapid and was significantly inhibited by the high-affinity PEPT1 substrate cyclacillin, assessed by the alteration of the area under the blood concentration-time curve for 30 min and the maximal concentration. Some amino acid derivatives of DMAE were transported by PEPT1, and their transport was dependent on the amino acids modified. In contrast to neutral substrates, cationic midodrine was taken up extensively at alkaline pH, and this pH profile was reproduced by a 14-state model of PEPT1, which we recently reported. These findings indicate that PEPT1 can transport midodrine and contributes to the high bioavailability of this drug and that Gly modification of DMAE is desirable for a prodrug of DMAE. Copyright

A process for the preparation of midodrine

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Example 3, (2010/01/31)

The invention provides a process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide of the formula 1 by hydrogenolysis of substituted 2-dibenzylamino-N-[2-(2',5'-dimethoxyphenyl)-2-hydroxy-ethyl]acetamide having the formula (5), wherein Ar and Ar' are aryl groups.

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