Iridium-catalyzed direct arene C-H bond amidation with sulfonyl- and aryl azides
Iridium-catalyzed direct ortho C-H amidation of arenes has been shown to work well with sulfonyl- and aryl azides as the nitrogen source. The reaction proceeds efficiently with a broad range of substrates bearing conventional directing groups with excellent functional group compatibility under mild conditions. In addition, substrates forming not only 5- but also 6-membered iridacycle intermediates undergo the C-H amidation with high selectivity.
Lee, Donggun,Kim, Youngchan,Chang, Sukbok
p. 11102 - 11109
(2013/11/19)
Ruthenium-catalyzed direct C-H amidation of arenes including weakly coordinating aromatic ketones
C-H activation: The ruthenium-catalyzed direct sp2 C-H amidation of arenes by using sulfonyl azides as the amino source is presented (see scheme). A wide range of substrates were readily amidated including arenes bearing weakly coordinating groups. Synthetic utility of the thus obtained products was demonstrated in the preparation of biologically active heterocycles. Copyright
Kim, Jiyu,Kim, Jinwoo,Chang, Sukbok
supporting information
p. 7328 - 7333
(2013/06/27)
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