- SYSTEM FOR CONTINUOUS MANUFACTURING OF SODIUM SARCOSINATE
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The invention relates to a system for continuous manufacturing of sodium sarcosinate. The system for continuous manufacturing of sodium sarcosinate in high pressure apparatus includes steps of : (a) mixing sodium chloroacetate solution with methylamine solution. (b)amination of mixed solution of sodium chloroacetate and methylamine under high pressure to obtain product of amination.(c)separating product of amination to obtain sodium sarcosinate. System for continuous manufacturing of sodium sarcosinate comprises: amination of mixed solution of sodium chloroacetate and methylamine under high pressure with continuous module to simplify process and improve reaction efficiency.
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Paragraph 0009-0014
(2017/11/01)
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- Process for the preparation of creatine water (by machine translation)
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The invention discloses a preparation method of creatine monohydrate, and provides the preparation method of the creatine monohydrate. The method comprises the following steps: step 1, carrying out a nucleophilic substitution reaction on a glycolonitrile aqueous solution and a methylamine aqueous solution for 1 to 6 hours at a temperature of 10 DEG C to 40 DEG C so as to generate methylamino acetonitrile; step 2, carrying out a hydrolysis reaction on the methylamino acetonitrile reaction liquid obtained in the step 1 for 2 to 6 hours at the temperature of 60 DEG C to 80 DEG C and in the presence of sodium hydroxide so as to obtain a sodium sarcosinate aqueous solution; step 3, regulating pH to 9 to 12 and carrying out a condensation reaction on the sodium sarcosinate aqueous solution and the cyanamide for 1 to 6 hours at the temperature of 50 DEG C to 90 DEG C so as to obtain the creatine monohydrate. The method is moderate in reaction condition, less in byproduct, high in yield and suitable for industrial production. The structure of the creatine monohydrate is as shown in the specification.
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Paragraph 0041; 0042
(2016/10/07)
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- General Synthesis of Amino Acid Salts from Amino Alcohols and Basic Water Liberating H2
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An atom-economical and environmentally friendly method to transform amino alcohols to amino acid salts using just basic water, without the need of pre-protection or added oxidant, catalyzed by a ruthenium pincer complex, is developed. Water is the solvent, the source of the oxygen atom of the carboxylic acid group, and the actual oxidant, with liberation of dihydrogen. Many important and useful natural and unnatural amino acid salts can be produced in excellent yields by applying this new method.
- Hu, Peng,Ben-David, Yehoshoa,Milstein, David
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supporting information
p. 6143 - 6146
(2016/06/09)
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- Process for Preparing Creatine, Creatine Monohydrate or Guanidinoacetic Acid
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A process for producing creatine, creatine monohydrate or guanidinoacetic acid is proposed, wherein firstly N-methylethanolamine or ethanolamine is catalytically dehydrogenated in each case in alkaline solution and the sarcosinate or glycinate solutions that are obtained in this manner are finally reacted under acidic conditions with a guanylating agent such as for example O-alkylisourea or cyanamide. In this manner products are obtained in high yields and very good purity where in contrast to the prior art no traces whatsoever of hydrocyanic acid, formaldehyde, chloroacetic acid or ammonia are present. The formation of the toxicologically critical dihydrotriazine is also avoided.
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Page/Page column 2
(2009/07/10)
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