- Simple and efficient: Ethylene glycol isonitrile gold(I) chlorides for the formation and stabilization of gold nanoparticles
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Ethylene glycol isonitriles C≡N(CH2CH2O) nCH3 (5a, n = 1; 5b, n = 3; 5c, n = 4) with different chain lengths were prepared by using straightforward synthesis methodologies including the Gabriel synthesis and an Appel-type reaction protocol. Upon treatment with [AuCl(SMe)2], compounds 5a-c gave the corresponding isocyanide gold(I) chlorides [AuCl{C≡N(CH2CH2O) nCH3}] (7a, n = 1; 7b, n = 3; 7c, n = 4). Single-crystal X-ray diffraction studies reveal a polymeric (7a) or dimeric (7c) structure with aurophilic interactions. Gold(I) complexes 7a-c were applied in the formation and stabilization of gold nanoparticles (AuNPs). The isonitriles with their ethylene glycol functionalities, which provide multiple donating capabilities, are able to stabilize the encapsulated gold colloids. The reduction of 7a-c by the addition of Na[BH4] in tetrahydrofuran or methanol produces AuNPs without the further addition of any stabilizer, since metal-organic 7a-c combine the stabilizing component and gold source in one molecule. The dependency of different solvents, concentrations, and varying ethylene glycol chain lengths on the NP size and size distribution is reported. Characterization by TEM, UV/Vis spectroscopy, and XRPD revealed that AuNPs are formed with a size between 6.4(±1.4) to 9.5(±2.3) nm in methanol and 18.2(±2.3) to 27.2(±3.5) nm in tetrahydrofuran. Copyright
- Tuchscherer, Andre,Schaarschmidt, Dieter,Schulze, Steffen,Hietschold, Michael,Lang, Heinrich
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p. 4421 - 4428
(2011/11/30)
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- Preparation and biodistribution of novel 99mTc(CO) 3-CNR complexes for myocardial imaging
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We evaluated lipophilicity and biodistribution of a series of 99mTc(CO)3-ether isonitrile complexes to determine whether different lipophilicity and structure of isonitrile ligands would improve the imaging properties of the radiopharmaceutical for the heart. Novel 99mTc(CO)3-MIBI analogs were prepared and analyzed by radio-HPLC, and their lipophilicity was determined. These new complexes could be bi- or tri-substituted in specified pH conditions like 99mTc(CO) 3-MIBI. These new complexes exhibited low liver, lungs and blood uptake compared with [99mTc(CO)3(MIBI)3] + though their heart uptake was not so high. Among these complexes, [99mTc(CO)3(EPI)2(OH2)]+ showed higher target to non-target ratios at 5 and 30 min post-injection than that of [99mTc(CO)3(MIBI)3]+. Copyright
- Hao, Guiyang,Zang, Jianying,Liu, Boli
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