- Efficient copper-catalyzed Michael addition of acrylic derivatives with primary alcohols in the presence of base
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A novel and efficient copper-catalyzed Michael addition of acrylic derivatives with primary alcohols in the presence of base has been developed. The protocol uses readily available acrylic derivatives and primary alcohols as the starting materials, inexpensive CuCl2 as the catalyst, and the corresponding addition products were obtained in moderate to excellent yields.
- Wang, Feng,Yang, Haijun,Fu, Hua,Pei, Zhichao
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supporting information
p. 517 - 519
(2013/02/23)
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- Tetrapeptidehydrazide derivatives
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Novel tetrapeptidehydrazide derivatives, inclusive of a pharmacologically acceptable acid addition salt thereof, which has the general formula (I): STR1 [wherein R1 is hydrogen or lower alkyl; R2 is hydrogen or the side chain of a D-α-amino acid; R3 is hydrogen or lower alkyl; R4 is hydrogen, or a saturated or unsaturated and straight or branched lower aliphatic acyl group which may optionally be substituted by hydroxy, amino, lower alkoxy, halogen, oxo, lower alkylthio or lower alkylthiooxide], are useful as analgesics.
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