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(5S)-5-CYANO-L-PROLINE ETHYL ESTER is a chemical compound with the molecular formula C8H12N2O2, derived from L-proline, an essential amino acid that plays a crucial role in protein synthesis. (5S)-5-CYANO-L-PROLINE ETHYL ESTER features an ethyl ester group, which enhances its lipophilicity, facilitating its ability to cross cell membranes. Its unique structure and properties render it a valuable building block in the pharmaceutical industry for the development of new drugs and molecular probes.

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  • 435274-88-7 Structure
  • Basic information

    1. Product Name: (5S)-5-CYANO-L-PROLINE ETHYL ESTER
    2. Synonyms: H-L-PRO(5S-CN)-OET;(5S)-5-CYANO-L-PROLINE ETHYL ESTER;L-Proline, 5-cyano-, ethyl ester, (5S)- (9CI);Ethyl (2S,5S)-5-cyano-2-pyrrolidinecarboxylate;(5S)-5-Cyano-L-Pro ethyl ester
    3. CAS NO:435274-88-7
    4. Molecular Formula: C8H12N2O2
    5. Molecular Weight: 168.19
    6. EINECS: N/A
    7. Product Categories: GLYCINESCAFFOLD;PYRROLE
    8. Mol File: 435274-88-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 290.1±40.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.13±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 4.79±0.10(Predicted)
    10. CAS DataBase Reference: (5S)-5-CYANO-L-PROLINE ETHYL ESTER(CAS DataBase Reference)
    11. NIST Chemistry Reference: (5S)-5-CYANO-L-PROLINE ETHYL ESTER(435274-88-7)
    12. EPA Substance Registry System: (5S)-5-CYANO-L-PROLINE ETHYL ESTER(435274-88-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 435274-88-7(Hazardous Substances Data)

435274-88-7 Usage

Uses

Used in Pharmaceutical Industry:
(5S)-5-CYANO-L-PROLINE ETHYL ESTER is used as a chemical precursor for the synthesis of various drugs and compounds. Its enhanced lipophilicity allows for improved cell membrane permeability, which can be advantageous in drug delivery and absorption. This characteristic makes it a promising candidate for the development of pharmaceutical agents targeting specific biological pathways or receptors.
Additionally, due to its structural features, (5S)-5-CYANO-L-PROLINE ETHYL ESTER can be utilized in the creation of molecular probes for research purposes. These probes can help in understanding complex biological processes and mechanisms, potentially leading to the discovery of novel therapeutic targets and treatments.

Check Digit Verification of cas no

The CAS Registry Mumber 435274-88-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,3,5,2,7 and 4 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 435274-88:
(8*4)+(7*3)+(6*5)+(5*2)+(4*7)+(3*4)+(2*8)+(1*8)=157
157 % 10 = 7
So 435274-88-7 is a valid CAS Registry Number.

435274-88-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl (2S,5S)-5-cyanopyrrolidine-2-carboxylate

1.2 Other means of identification

Product number -
Other names Ethyl(5S)-5-cyano-L-prolinate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:435274-88-7 SDS

435274-88-7Relevant articles and documents

An efficient synthesis of substituted prolines by the selective reduction and reductive cyanation of 2-pyrrolidones

Xia, Qian,Ganem, Bruce

, p. 1597 - 1598 (2002)

Substituted pyrrolidones undergo selective reduction using Cp2ZrHCl (Schwartz's reagent) to form Δ1-pyrrolines, which can be isolated or directly cyanated and hydrolyzed to the corresponding proline. Short syntheses of glutamic semialdehyde (ethyl ester), the marine metabolite (2S,5S)-pyrrolidine-2,5-dicarboxylic acid, and the conformationally constrained amino acid 5,5-dimethylproline, are reported.

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