A series of 2-alkyl-4-arylimidazoles were prepared and their binding affinities to the site-2 sodium (Na+) channel were determined. SAR studies led to highly potent Na+ channel blockers.
Liberatore, Anne-Marie,Schulz, Jocelyne,Pommier, Jacques,Barthelemy, Marie-Anne,Huchet, Marion,Chabrier, Pierre-Etienne,Bigg, Dennis
p. 3521 - 3523
(2007/10/03)
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