437652-07-8Relevant articles and documents
Method for synthesizing [...] reach silom
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Paragraph 0082-0085, (2017/01/17)
The invention discloses a dronedarone synthesis method. According to the method, 4-[3-(dibutylamino)propoxy]methyl benzoate, 4-[3-(dibutylamino)propoxy]benzoic acid hydrochloride, 4-[3-(dibutylamino)propoxy]benzoyl chloride, 2-bromohexanoyl chloride, p-methoxyacetanilide, 3-(2-bromohexanoyl chloride)-4-hydroxyacetanilide, N-2-butyl-5-benzofuranamine hydrochloride, N-[(2-butyl-2,3-2H-5-benzofuran)methanesulfonamide], N-2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuran]-methanesulfonamide and dronedarone are obtained through step-reactions. The dronedarone synthesis method is simple in process, convenient to operate and high in rate of production.
Methanesulphonamido-benzofuran, preparation method and use thereof as synthesis intermediate
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Page/Page column 4, (2008/06/13)
The invention relates to 2-butyl-5-(methanesulfonamido)benzofuran, its preparation and its use. This compound is a synthesis intermediate, in particular for the preparation of dronedarone.