- BENZO RING DERIVATIVE WITH B2 RECEPTOR AGONIST AND M3 RECEPTOR ANTAGONIST ACTIVITIES AND USE THEREOF IN MEDICINE
-
A compound represented by general formula (I), or a stereoisomer, a hydrate, a metabolite, a solvate, a pharmaceutically acceptable salt, a cocrystal, or a prodrug thereof, the preparation method thereof, and use thereof in the manufacture of a medicament for treatment of an airway obstructive disease, wherein the substituents are defined as in the specification.
- -
-
Paragraph 0149-0151
(2018/09/29)
-
- 6-SUBSTITUTED-3H-1,3-BENZOTHIAZOL-2-ONE COMPOUNDS AS TARP-GAMMA 8 DEPENDENT AMPA RECEPTOR ANTAGONISTS
-
A TARP ?8 dependant AMPA receptor antagonist of the formula: wherein X is CH or N; A is; and R1 is as defined herein; its pharmaceutically acceptable salts, uses, and methods for its preparation are described.
- -
-
Page/Page column 77; 78
(2016/01/29)
-
- A Simple strategy for the preparation of 6-substituted 3H-benzoxazol-2-ones and 3H-benzothiazol-2-ones
-
The double metallation of 6-bromo-3H-benzothiazol-2-one and 6-bromo-3H-benzoxazol-2-one with methyl magnesium bromide and alkyllithium bases is described. Alkylation with a variety of electrophiles occurs at the 6-position of the heterocycles in good yiel
- Deorazio, Russell J.,Maeng, Jun-Ho,Manning, David D.,Sherer, Brian A.,Scott, Ian L.,Nikam, Sham S.
-
experimental part
p. 3551 - 3555
(2011/10/09)
-