- Effects of gentianine on the production of pro-inflammatory cytokines in male Sprague-Dawley rats treated with lipopolysaccharide (LPS)
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This study was undertaken to elucidate the mechanism of anti-inflammatory action of gentianine, a constituent of Gentiana Macrophylla. The effects of gentianine on lipopolysacharide (LPS)-induced production of pro-inflammatory cytokines were investigated in male Sprague-Dawley rats. For the first time, we found that oral administration of gentianine (10-100 mg/kg) suppressed the increases in tumor necrosis factor-α (TNF-α) (ED50, 37.7 mg/kg) and interleukin (IL)-6 (ED50, 38.5 mg/kg) in the sera from the rats challenged with bacterial LPS (100 μg/kg; i.p.). However, LPS induced production of other interleukins, such as IL-α, was not significantly altered by gentianine. These results suggest that the potential anti-inflammatory action of gentianine might be at least partly based on the suppressed production of TNF-α and IL-6.
- Kwak, Wie-Jong,Kim, Joo-Hyon,Ryu, Keun-Ho,Cho, Yong-Baik,Jeon, Sun-Duck,Moon, Chang-Kiu
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- NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
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This invention relates to novel pyridine derivatives having an inhibitory effect on production of cytokines, which are involved in inflammatory responses, thus suggesting its usefulness as therapeutic agents for treating diseases related to inflammation, immune, chronic inflammation as well as an agent having an anti-inflammatory and analgesic effect. Further, this invention relates to a method of manufacturing the same and a pharmaceutical composition containing the same.
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(2008/06/13)
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