- 5- OR 7-AZAINDAZOLES AS BETA-LACTAMASE INHIBITORS
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The present invention relates to β-lactamase inhibitors having the following general formula (I): wherein R1-R4 and X1-X2 are defined in the specification, pharmaceutical composition thereof, and use thereof for the treatment of a bacterial infection, alone or in combination with β-lactam antibiotics and/or other antibiotics and/or other β-lactamase inhibitors.
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Page/Page column 116
(2020/09/19)
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- Gas-phase synthesis of pyrazolo[3,4- b ]pyridin-4-ones
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Flash vacuum pyrolysis (FVP) at 500-600 °C of 1-substituted pyrazolylaminomethylene derivatives of Meldrum's acid provides 1-substituted pyrazolo[3,4-b]pyridin-4-ones in high yields. If the 1-substituent is a tert-butyl group, FVP at 750-850 °C causes elimination of 2-methyl-1-propene to give the parent pyrazolo[3,4-b]pyridin-4-one.
- Mackay, Martha,Nortcliffe, Andrew,McNab, Hamish,Hulme, Alison N.
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p. 242 - 248
(2015/05/05)
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- Syntheses of 1-substituted-3-aminopyrazoles
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A series of 1-substituted-3-aminopyrazoles were prepared via Chan-Lam coupling reactions, alkylation, and pyrazole ring formation.
- Ji, Nan,Meredith, Erik,Liu, Donglei,Adams, Christopher M.,Artman III, Gerald D.,Jendza, Keith C.,Ma, Fupeng,Mainolfi, Nello,Powers, James J.,Zhang, Chun
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experimental part
p. 6799 - 6801
(2011/03/18)
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- Novel aminopyridine derivatives having aurora a selective inhibitory action
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The present invention relates to a compound of formula I: wherein: R1 is a hydrogen atom, F, CN, etc.; R1′ is a hydrogen atom or lower alkyl which may be substituted; R2 is O, S, SO, SO2, etc.; R3 is
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Page/Page column 63
(2008/06/13)
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