442901-00-0

Basic information

• Product Name: 1-(3-HYDROXY-6-METHOXY-2-METHYLTETRAHYDRO-2H-PYRAN-4-YL)GUANIDINE
• Synonyms: 1-(3-HYDROXY-6-METHOXY-2-METHYLTETRAHYDRO-2H-PYRAN-4-YL)GUANIDINE
• CAS NO: 442901-00-0
• Molecular Formula: C8H17N3O3
• Molecular Weight: 203.24
• Mol File: 442901-00-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(3-HYDROXY-6-METHOXY-2-METHYLTETRAHYDRO-2H-PYRAN-4-YL)GUANIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-HYDROXY-6-METHOXY-2-METHYLTETRAHYDRO-2H-PYRAN-4-YL)GUANIDINE(442901-00-0)
• EPA Substance Registry System: 1-(3-HYDROXY-6-METHOXY-2-METHYLTETRAHYDRO-2H-PYRAN-4-YL)GUANIDINE(442901-00-0)

Safety Data

• Hazardous Substances Data: 442901-00-0(Hazardous Substances Data)

Upstream product

• 77398-20-0 methyl-3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside 

Relevant articles and documents

Amidination of amines under microwave conditions using recyclable polymer-bound 1H-pyrazole-1-carboxamidine

A convenient one-step transformation of primary and secondary amines into the corresponding unprotected guanidines using 4-benzyl-3,5-dimethyl-1H- pyrazole-1-carboxamidine and its polymer-bound variant is described. The scopes and limitations of the method, the microwave-assistance of amidination as well as a recycling protocol are examined. Georg Thieme Verlag Stuttgart.

A new reagent and its polymer-supported variant for the amidination of amines

New reagents for the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring, a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition, the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity.