443-89-0

Basic information

• Product Name: 2-Fluoro-6-methylaniline
• Synonyms: 2-FLUORO-6-METHYLANILINE;2-AMINO-3-FLUOROTOLUENE;2-FLUORO-6-METHYLANILINE,98%;2-Amino-3-fluorotoluene 6-Fluoro-o-toluidine;2-Fluoro-6-methylaniline 97+%;Benzenamine, 2-fluoro-6-methyl-
• CAS NO: 443-89-0
• Molecular Formula: C₇H₈FN
• Molecular Weight: 125.14
• EINECS: 204-359-6
• Product Categories: Fluorin-contained toluene series;Halogen toluene;Amines;C7Chemical Synthesis;New Products for Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Aryl Fluorinated Building Blocks;Building Blocks;C7;C7-C8;Chemical Synthesis;Fluorinated Building Blocks;Nitrogen Compounds;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 443-89-0.mol

Chemical Properties

• Melting Point: 0°C
• Boiling Point: 0°C
• Flash Point: 0°C
• Appearance: /
• Density: 1.082 g/mL at 25 °C
• Vapor Pressure: 0.644mmHg at 25°C
• Refractive Index: n20/D 1.536
• Storage Temp.: 2-8°C
• PKA: 3.06±0.10(Predicted)
• CAS DataBase Reference: 2-Fluoro-6-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-6-methylaniline(443-89-0)
• EPA Substance Registry System: 2-Fluoro-6-methylaniline(443-89-0)

Safety Data

• Hazard Codes: T,Xn
• Statements: 20/21/22-36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39-60-23
• RIDADR: UN2810
• WGK Germany: 3
• Hazardous Substances Data: 443-89-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-6-methylaniline is used as a key intermediate in the synthesis of arylmethylene heterocyclic compounds. These compounds serve as Kv1.3 potassium shaker channel blockers, which are important in the development of treatments for autoimmune diseases such as multiple sclerosis and rheumatoid arthritis. The blocking of Kv1.3 channels helps modulate the immune response and reduce inflammation.
Additionally, 2-Fluoro-6-methylaniline can be utilized in the preparation of other bioactive molecules and pharmaceutical agents, highlighting its significance in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C7H8FN/c1-5-3-2-4-6(8)7(5)9/h2-4H,9H2,1H3

Upstream product

• 3013-27-2 1-fluoro-3-methyl-2-nitro-benzene 

Downstream Products

• 933449-53-7 pyridine-2-carboxylic acid (2-fluoro-6-methyl-phenyl)-amide 
• 883502-14-5 1-fluoro-2-iodo-3-methylbenzene 
• 771-45-9 N-(2-fluoro-6-methylphenyl)acetamide 

Relevant articles and documents

Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides

Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonamides, e.g., 5,7-dimethyl-N-(2,6-dichlorophenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide and their agriculturally acceptable salts are prepared. These compounds and compositions containing them are useful for the control of unwanted vegetation. Novel substituted triazolo[1,5-a]pyrimidine-2-sulfonyl chlorides and substituted anilines and their use as intermediates are also described.

Novel substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides and compositions and method for inhibiting pollen formation in corn

Novel compounds, e.g., 5,7-dimethyl-N-(2,6-dichlorolphenyl)-1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamide and their compositions and use in the control of weeds and in the suppression of nitrification of ammonium nitrogen in soil. Other novel compounds and their compositions and use in the inhibition of bolting in sugar beets. Other novel compounds and their compositions and use as plant gametocides.