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Tert-butyl2-Oxo-4-(tosyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate is a complex organic molecule characterized by the presence of a tert-butyl group, an oxo group, and a tosyloxy group attached to a central 2,5-dihydro-1H-pyrrole-1-carboxylate structure. Tert-butyl2-Oxo-4-(tosyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate is known for its versatility in organic synthesis and as a reagent for a variety of chemical reactions.

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  • tert-butyl 4-[(4-methylbenzenesulfonyl)oxy]-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate

    Cas No: 443680-33-9

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  • 443680-33-9 Structure
  • Basic information

    1. Product Name: Tert-butyl2-Oxo-4-(tosyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate
    2. Synonyms: Tert-butyl2-Oxo-4-(tosyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate
    3. CAS NO:443680-33-9
    4. Molecular Formula: C16H19NO6S
    5. Molecular Weight: 353
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 443680-33-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Tert-butyl2-Oxo-4-(tosyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: Tert-butyl2-Oxo-4-(tosyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate(443680-33-9)
    11. EPA Substance Registry System: Tert-butyl2-Oxo-4-(tosyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate(443680-33-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 443680-33-9(Hazardous Substances Data)

443680-33-9 Usage

Uses

Used in Organic Synthesis:
Tert-butyl2-Oxo-4-(tosyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate is used as a reagent in organic synthesis for the preparation of different compounds. Its unique structure and functional groups contribute to the formation of a wide range of organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Tert-butyl2-Oxo-4-(tosyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate is utilized for the production of pharmaceutical drugs. Its presence in the synthesis process allows for the creation of various drug molecules with potential therapeutic applications.
Used in Materials Science:
Tert-butyl2-Oxo-4-(tosyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate is also employed in the field of materials science for the synthesis of advanced materials. Its versatile intermediate properties enable the development of new materials with specific properties for various applications.
Used as a Versatile Intermediate:
The presence of the tosyloxy group in Tert-butyl2-Oxo-4-(tosyloxy)-2,5-dihydro-1H-pyrrole-1-carboxylate makes it a valuable versatile intermediate for the preparation of different compounds with varied applications across various industries. Its ability to participate in multiple chemical reactions allows for the creation of a diverse range of products.

Check Digit Verification of cas no

The CAS Registry Mumber 443680-33-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,4,3,6,8 and 0 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 443680-33:
(8*4)+(7*4)+(6*3)+(5*6)+(4*8)+(3*0)+(2*3)+(1*3)=149
149 % 10 = 9
So 443680-33-9 is a valid CAS Registry Number.

443680-33-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-oxo-4-(toluene-4-sulfonyloxy)-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester

1.2 Other means of identification

Product number -
Other names tert-butyl 2,5-dihydro-2-oxo-4-p-tosyloxy-1H-pyrrole-1-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:443680-33-9 SDS

443680-33-9Relevant articles and documents

COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS

-

, (2021/02/05)

Provided are methods for treating neurological disorders using compounds of Formula (I), and pharmaceutically acceptable salts and compositions thereof.

P300/CBP HAT INHIBITORS

-

, (2019/09/04)

Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone acetyltransferase (HAT).

TYK2 INHIBITORS AND USES THEREOF

-

Paragraph 001030, (2017/03/21)

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Aminoheteroaryl benzamides as kinase inhibitors

-

, (2016/02/15)

The present invention provides a compound of Formula (I) or a salt thereof; and therapeutic uses of these compounds. The present invention further provides pharmaceutical compositions comprising these compounds, and compositions comprising these compounds with a therapeutic co-agent.

TAMBJAMINES AND B-RING FUNCTIONALIZED PRODIGININES

-

Page/Page column 17; 18; 26, (2016/11/17)

Embodiments of tambjamines and B-ring functionalized prodiginines are disclosed. Methods of synthesizing and using the disclosed compounds are also disclosed. Some embodiments of the disclosed compounds have antimalarial activity. Certain embodiments of t

Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials

Kancharla, Papireddy,Kelly, Jane Xu,Reynolds, Kevin A.

, p. 7286 - 7309 (2015/10/05)

Synthesis and antimalarial activity of 94 novel bipyrrole tambjamines (TAs) and a library of B-ring functionalized tripyrrole prodiginines (PGs) against a panel of Plasmodium falciparum strains are described. The activity and structure-activity relationsh

Short synthesis of 4-aryl-3-pyrrolin-2-ones

Yoon-Miller, Sarah J.P.,Opalka, Suzanne M.,Pelkey, Erin T.

, p. 827 - 830 (2007/10/03)

A three step, convergent synthesis of 4-aryl-3-pyrrolin-2-ones from a tetramic acid has been developed. The key transformation utilized a Suzuki-Miyaura cross-coupling reaction between a 4-tosyloxy-3-pyrrolin-2-one and an arylboronic acid. This work also

Efficient total synthesis of pulchellalactam, a CD45 protein tyrosine phosphatase inhibitor

Li, Wen-Ren,Lin, Sung Tsai,Hsu, Nai-Mu,Chern, Meei-Shiou

, p. 4702 - 4706 (2007/10/03)

A new approach to a CD45 protein tyrosine phosphatase inhibitor, pulchellalactam, is described. The key step of the sequence involves addition and elimination of an enolic lactam in a single step and 70% yield, employing an organocuprate reagent. The resulting α,β-unsaturated lactam could be condensed with isobutyraldehyde to produce Z-pulchellalactam or converted into siloxypyrrole, which was subjected to the BF3·Et2O-promoted coupling reaction with isobutyraldehyde to afford E-pulchellalactam after E1-cB elimination and TFA deprotection. This first total synthesis afforded Z-pulchellalactam in six steps and 32% overall yield from Boc-glycine. The same sequence of reactions could also be applied to the liquid- or solid-phase synthesis of trifunctionalized pulchellalactam derivatives.

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