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Product FOB Price Min.Order Supply Ability Supplier
Boc-Glycine
Cas No: 4530-20-5
No Data 1 Gram 5 Metric Ton/Month SICHUAN TONGSHENG AMINOACID CO.LTD Contact Supplier
Boc-Glycine Manufacturer/High quality/Best price/In stock
Cas No: 4530-20-5
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
99% up Boc-Gly-OH N-(tert-Butoxycarbonyl)glycine Boc-Glycine 4530-20-5
Cas No: 4530-20-5
No Data 25 Kilogram 50 Metric Ton/Month Sinoway Industrial Co., Ltd. Contact Supplier
High quality Boc-Gly-OH supplier in China
Cas No: 4530-20-5
No Data 1 Kilogram 50 Metric Ton/Month Simagchem Corporation Contact Supplier
High purity Various Specifications BOC-Glycine CAS:4530-20-5
Cas No: 4530-20-5
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Boc-l-glycine
Cas No: 4530-20-5
USD $ 1.0-2.0 / Metric Ton 1 Metric Ton 100 Metric Ton/Week Hebei yanxi chemical co.,LTD. Contact Supplier
N-tert-Butoxycarbonylglycine
Cas No: 4530-20-5
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
BOC-Glycine
Cas No: 4530-20-5
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Factory Supply N-(tert-butoxycarbonyl)glycine
Cas No: 4530-20-5
No Data 1 1 Ality Chemical Corporation Contact Supplier
BOC-Gly-OH
Cas No: 4530-20-5
No Data 23 Metric Ton 3000 Kilogram/Month ORCHID CHEMICAL SUPPLIES LTD Contact Supplier

4530-20-5 Usage

Chemical Properties

White To Off-White Powder

Uses

BOC-Glycine is used in the composition of drugs containing Ketoprofen, and Sodium hyaluronate as antiinflammatory agents.

Synthesis Reference(s)

Tetrahedron Letters, 16, p. 4393, 1975 DOI: 10.1016/S0040-4039(00)91133-X
InChI:InChI=1/C7H13NO4/c1-7(2,3)12-6(11)8-4-5(9)10/h4H2,1-3H3,(H,8,11)(H,9,10)/p-1

4530-20-5 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (B1185)  N-(tert-Butoxycarbonyl)glycine  >98.0%(T) 4530-20-5 5g 180.00CNY Detail
TCI America (B1185)  N-(tert-Butoxycarbonyl)glycine  >98.0%(T) 4530-20-5 25g 540.00CNY Detail
Alfa Aesar (A11579)  N-Boc-glycine, 98+%    4530-20-5 5g 165.0CNY Detail
Alfa Aesar (A11579)  N-Boc-glycine, 98+%    4530-20-5 25g 396.0CNY Detail
Alfa Aesar (A11579)  N-Boc-glycine, 98+%    4530-20-5 100g 1315.0CNY Detail
Aldrich (15420)  Boc-Gly-OH  ≥99.0% (T) 4530-20-5 15420-5G 313.56CNY Detail
Aldrich (15420)  Boc-Gly-OH  ≥99.0% (T) 4530-20-5 15420-25G 893.88CNY Detail
Aldrich (15420)  Boc-Gly-OH  ≥99.0% (T) 4530-20-5 15420-100G 2,416.05CNY Detail

4530-20-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name t-Butoxycarbonylglycine

1.2 Other means of identification

Product number -
Other names N-Boc-glycine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4530-20-5 SDS

4530-20-5Synthetic route

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

glycine
56-40-6

glycine

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With potassium hydroxide In 1,4-dioxane; water at 20℃; for 12h;100%
Stage #1: glycine With sodium hydroxide In 1,4-dioxane; water at 0℃; for 0.25h;
Stage #2: di-tert-butyl dicarbonate In 1,4-dioxane; water at 0 - 20℃;
100%
With sodium hydroxide In 1,4-dioxane100%
2-oxo-2-phenylethyl 2-(tert-butoxycarbonylamino)acetate
83316-95-4

2-oxo-2-phenylethyl 2-(tert-butoxycarbonylamino)acetate

A

BOC-glycine
4530-20-5

BOC-glycine

B

acetophenone
98-86-2

acetophenone

Conditions
ConditionsYield
With N,N,N',N'-tetramethyl-o-phenylenediamine In acetonitrile for 2h; Irradiation;A 100%
B n/a
tert-butoxycarbonylamino-acetic acid 4-tert-butyl-benzyl ester

tert-butoxycarbonylamino-acetic acid 4-tert-butyl-benzyl ester

A

BOC-glycine
4530-20-5

BOC-glycine

B

4-tert-butyltoluene
98-51-1

4-tert-butyltoluene

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal for 3h;A 100%
B n/a
(1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl (tert-butoxycarbonyl)glycinate

(1,1-dioxido-4-oxo-3-phenyl-4H-thiochromen-2-yl)methyl (tert-butoxycarbonyl)glycinate

A

BOC-glycine
4530-20-5

BOC-glycine

B

C16H10O3S
1033736-87-6

C16H10O3S

Conditions
ConditionsYield
In chloroform-d1 for 0.25h; Solvent; Photolysis; Inert atmosphere;A 97%
B n/a
glycine
56-40-6

glycine

BOC derivative

BOC derivative

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With sodium hydroxide In 1,4-dioxane at 20℃; for 8h;95%
tert-butyl (2,4-dioxo-3-azaspiro[5,5]undecan-3-yl) carbonate

tert-butyl (2,4-dioxo-3-azaspiro[5,5]undecan-3-yl) carbonate

glycine
56-40-6

glycine

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With sodium hydroxide In water; acetone at 25℃; for 12h;94%
(N-hydroxy-5-norbornene-2,3-diformylimino)tert-butyl ester
64205-15-8

(N-hydroxy-5-norbornene-2,3-diformylimino)tert-butyl ester

glycine
56-40-6

glycine

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With tertiary amine In 1,4-dioxane; water for 3h;85%
tert-butyl 4,6-dimethoxy-1,3,5-triazinyl carbonate
909114-65-4

tert-butyl 4,6-dimethoxy-1,3,5-triazinyl carbonate

glycine
56-40-6

glycine

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With triethylamine In methanol at 20℃; for 0.5h;85%
4-nitrobenzyl N-(tert-butoxycarbonyl)glycinate
79113-14-7

4-nitrobenzyl N-(tert-butoxycarbonyl)glycinate

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With sodium dithionite; sodium carbonate In acetonitrile80%
glycine
56-40-6

glycine

1-tert-butoxycarbonyloxybenzotriazole
89037-64-9

1-tert-butoxycarbonyloxybenzotriazole

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With triethylamine In 1,4-dioxane; water for 0.166667h; Ambient temperature;80%
2-oxo-2-phenylethyl 2-(tert-butoxycarbonylamino)acetate
83316-95-4

2-oxo-2-phenylethyl 2-(tert-butoxycarbonylamino)acetate

A

BOC-glycine
4530-20-5

BOC-glycine

B

(tert-butoxycarbonyl)glycine hydrazide
6926-09-6

(tert-butoxycarbonyl)glycine hydrazide

Conditions
ConditionsYield
With hydrazine hydrate In methanol Product distribution;A 75%
B 12%
N-Boc-glycine 2-(2-acetylphenyl)-1-methylethyl ester
618068-89-6

N-Boc-glycine 2-(2-acetylphenyl)-1-methylethyl ester

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
In acetonitrile for 3h; Photolysis;73%
(E)-3-methoxyallyl 2-((tert-butoxycarbonyl)amino)acetate
1080004-01-8

(E)-3-methoxyallyl 2-((tert-butoxycarbonyl)amino)acetate

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With zinc(II) chloride; lithium hexamethyldisilazane In tetrahydrofuran at -78 - 20℃; Inert atmosphere;59%
With potassium hexamethylsilazane; zinc(II) chloride In tetrahydrofuran at -78 - 20℃; Inert atmosphere;54%
tert-Butoxycarbonylamino-acetic acid (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl ester
42721-06-2

tert-Butoxycarbonylamino-acetic acid (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl ester

glycine ethyl ester hydrochloride
5680-79-5

glycine ethyl ester hydrochloride

A

BOC-glycine
4530-20-5

BOC-glycine

B

N-tert-butoxycarbonyl glycyl glycine methyl ester
53487-98-2

N-tert-butoxycarbonyl glycyl glycine methyl ester

Conditions
ConditionsYield
With 4-methyl-morpholine In N,N-dimethyl-formamide at 38℃; for 96h;A n/a
B 57%
glycine ethyl ester hydrochloride
5680-79-5

glycine ethyl ester hydrochloride

2,3,4,6-tetra-O-benzyl-1-O-(N-tert-butoxycarbonyl-glycyl)-β-D-glucopyranose
35909-78-5

2,3,4,6-tetra-O-benzyl-1-O-(N-tert-butoxycarbonyl-glycyl)-β-D-glucopyranose

A

BOC-glycine
4530-20-5

BOC-glycine

B

N-tert-butoxycarbonyl glycyl glycine methyl ester
53487-98-2

N-tert-butoxycarbonyl glycyl glycine methyl ester

Conditions
ConditionsYield
With 4-methyl-morpholine In N,N-dimethyl-formamide at 38℃; for 96h;A n/a
B 55%
C n/a
t-butyl malonate
541-16-2

t-butyl malonate

glycine
56-40-6

glycine

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With sodium carbonate In water; acetonitrile at -5 - 20℃;35%
Glycine tert-butyl ester
6456-74-2

Glycine tert-butyl ester

2-oxo-2-phenylethyl 2-(tert-butoxycarbonylamino)acetate
83316-95-4

2-oxo-2-phenylethyl 2-(tert-butoxycarbonylamino)acetate

A

BOC-glycine
4530-20-5

BOC-glycine

B

Boc-glycylglycine tert-butyl ester
5845-68-1

Boc-glycylglycine tert-butyl ester

Conditions
ConditionsYield
In ethyl acetate for 24h; Product distribution; Ambient temperature;A 10%
B 30%
tert-Butyl 4-nitrophenyl carbonate
13303-10-1

tert-Butyl 4-nitrophenyl carbonate

glycine
56-40-6

glycine

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With sodium hydroxide; tert-butyl alcohol
phosgene
75-44-5

phosgene

GlyOEt*HCl
459-73-4

GlyOEt*HCl

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With toluene Erwaermen des Reaktionsprodukts mit tert-Butylalkohol und anschliessenden Hydrolyse;
tert-butyl alcohol
75-65-0

tert-butyl alcohol

Glycine ethyl ester isocyanate
2949-22-6

Glycine ethyl ester isocyanate

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With triethylamine Behandeln des Reaktionsprodukts mit wss.NaOH und Dioxan;
tert-butyl chloroformate
24608-52-4

tert-butyl chloroformate

glycine
56-40-6

glycine

BOC-glycine
4530-20-5

BOC-glycine

Conditions
ConditionsYield
With sodium hydroxide
BOC-glycine
4530-20-5

BOC-glycine

benzylamine
100-46-9

benzylamine

Boc-glycine-benzylamide
19811-52-0

Boc-glycine-benzylamide

Conditions
ConditionsYield
Stage #1: BOC-glycine; benzylamine With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide for 0.0166667h;
Stage #2: With HATU for 18h;
100%
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;99%
With zirconium(IV) chloride In tetrahydrofuran at 70℃; for 24h; Molecular sieve; Inert atmosphere;99%
BOC-glycine
4530-20-5

BOC-glycine

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride
27894-50-4

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride

Nα-tert-butoxycarbonylglycyl-Nε-benzyloxycarbonyl-L-lysine methyl ester
32689-62-6

Nα-tert-butoxycarbonylglycyl-Nε-benzyloxycarbonyl-L-lysine methyl ester

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at -20 - 20℃; for 4h; Acylation;100%
Stage #1: BOC-glycine With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.5h; Cooling with ice;
Stage #2: methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;
92.2%
(i) Et3N, ClCO2iBu, (ii) /BRN= 3578476/, Et3N; Multistep reaction;
With 4-methyl-morpholine; triethylamine; isobutyl chloroformate 1) THF, -10 deg C, 15 min, 2) THF, 12 h; Yield given. Multistep reaction;
BOC-glycine
4530-20-5

BOC-glycine

L-alanine benzyl ester p-toluenesulfonate
42854-62-6

L-alanine benzyl ester p-toluenesulfonate

Boc-Gly-Ala-OBzl
63649-08-1

Boc-Gly-Ala-OBzl

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine100%
With TEA; diphenyl phosphoryl azide In N,N-dimethyl-formamide 1.) 0 deg C, 4 h; 2.) r.t., overnight;85%
Stage #1: BOC-glycine; L-alanine benzyl ester p-toluenesulfonate With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 0.166667h; Inert atmosphere;
Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 24h; Inert atmosphere;
BOC-glycine
4530-20-5

BOC-glycine

benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride
16652-71-4

benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

(S)-1-(2-tert-butoxycarbonylaminoacetyl)pyrrolidine-2-carboxylic acid benzyl ester
29776-78-1

(S)-1-(2-tert-butoxycarbonylaminoacetyl)pyrrolidine-2-carboxylic acid benzyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; triethylamine In chloroform100%
With benzotriazol-1-ol; triethylamine In chloroform100%
With benzotriazol-1-ol; triethylamine In chloroform100%
BOC-glycine
4530-20-5

BOC-glycine

L-valine benzyl ester p-toluenesulfonate salt
16652-76-9

L-valine benzyl ester p-toluenesulfonate salt

N-t-butoxycarbonylglycyl-L-valine benzyl ester
66415-00-7

N-t-butoxycarbonylglycyl-L-valine benzyl ester

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine100%
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 0 - 20℃; for 12h; Inert atmosphere;94%
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In N,N-dimethyl-formamide 1.) 0 deg C, 2.) overnight, 4 deg C;89%
With 4-methyl-morpholine; isobutyl chloroformate 1.) THF, -15 deg C, 2.) DMF, a) -15 deg C, 30 min, b) r.t., 30 min.; Yield given. Multistep reaction;
BOC-glycine
4530-20-5

BOC-glycine

(-)-8-phenylmenthol
65253-04-5

(-)-8-phenylmenthol

(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (tert-butoxycarbonyl)aminoacetate
117681-86-4

(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (tert-butoxycarbonyl)aminoacetate

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; for 13h;100%
Stage #1: BOC-glycine With dmap; dicyclohexyl-carbodiimide In dichloromethane at -30℃; for 0.166667h;
Stage #2: (-)-8-phenylmenthol In dichloromethane for 20h; Heating;
96%
With dmap; dicyclohexyl-carbodiimide93%
BOC-glycine
4530-20-5

BOC-glycine

2-(N-tert-butoxycarbonylamino)ethanol
26690-80-2

2-(N-tert-butoxycarbonylamino)ethanol

Conditions
ConditionsYield
Stage #1: BOC-glycine With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -15℃; for 0.25h;
Stage #2: With sodium tetrahydroborate In tetrahydrofuran; water at -15℃; for 1h;
100%
With diisopropoxytitanium(III) tetrahydroborate In dichloromethane for 4h; Ambient temperature;88%
With sodium bis(2-methoxyethoxy)aluminium dihydride In tetrahydrofuran; toluene at 0℃; for 2h;77.1%
BOC-glycine
4530-20-5

BOC-glycine

benzyl bromide
100-39-0

benzyl bromide

tert-butoxycarbonylamino-acetic acid benzyl ester
54244-69-8

tert-butoxycarbonylamino-acetic acid benzyl ester

Conditions
ConditionsYield
Stage #1: BOC-glycine With caesium carbonate In methanol pH=7;
Stage #2: benzyl bromide In N,N-dimethyl-formamide at 20℃; for 5h; Further stages.;
100%
Stage #1: BOC-glycine With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: benzyl bromide In N,N-dimethyl-formamide at 0℃; for 18h; Further stages;
100%
With triethylamine In N,N-dimethyl-formamide at 25℃; for 5h;54%
With caesium carbonate 1) MeOH, water, pH 7.0, 2) DMF, 5 h; Yield given. Multistep reaction;
With sodium iodide In acetone for 2h; Reflux; Inert atmosphere;
BOC-glycine
4530-20-5

BOC-glycine

ethyl iodide
75-03-6

ethyl iodide

N-(tert-buytoxycarbonyl)-N-ethylglycine
149794-10-5

N-(tert-buytoxycarbonyl)-N-ethylglycine

Conditions
ConditionsYield
Stage #1: BOC-glycine; ethyl iodide With sodium hydride In tetrahydrofuran at 0℃; for 1h;
Stage #2: In tetrahydrofuran at 0℃;
100%
Stage #1: BOC-glycine; ethyl iodide With sodium hydride In tetrahydrofuran at 0 - 20℃;
Stage #2: With citric acid In water pH=2 - 3;
100%
Stage #1: BOC-glycine; ethyl iodide With sodium hydride In tetrahydrofuran at 0 - 20℃;
Stage #2: With citric acid In water pH=2 - 3;
100%
BOC-glycine
4530-20-5

BOC-glycine

allyl bromide
106-95-6

allyl bromide

allyl 2-(tert-butoxycarbonylamino)acetate
124373-83-7

allyl 2-(tert-butoxycarbonylamino)acetate

Conditions
ConditionsYield
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 50℃; for 16h;100%
With N-ethyl-N,N-diisopropylamine for 0.666667h; Reflux;91%
With caesium carbonate In acetonitrile90%
BOC-glycine
4530-20-5

BOC-glycine

aniline
62-53-3

aniline

N-glycyl>aniline
27904-92-3

N-glycyl>aniline

Conditions
ConditionsYield
With dicyclohexyl-carbodiimide In tetrahydrofuran at 25℃; for 5h;100%
With fluorosulfonyl fluoride; N-ethyl-N,N-diisopropylamine In acetonitrile at 20℃; for 5h;99%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 20℃; for 6h;96.9%
BOC-glycine
4530-20-5

BOC-glycine

isobutyl chloroformate
543-27-1

isobutyl chloroformate

N-(t-butoxycarbonyl)glycyl i-butyl carbonate
66866-43-1

N-(t-butoxycarbonyl)glycyl i-butyl carbonate

Conditions
ConditionsYield
With 4-methyl-morpholine In tetrahydrofuran at -15℃; for 0.0833333h;100%
With 4-methyl-morpholine In tetrahydrofuran at -20℃; for 0.05h;
BOC-glycine
4530-20-5

BOC-glycine

tetrakis-5,10,15,20-(o-aminophenyl)porphyrin
52199-35-6

tetrakis-5,10,15,20-(o-aminophenyl)porphyrin

α,α,α,α-5,10,15,20-tetrakis-(2-(N-[(2-t-butylcarbamoyl)ethanamide]phenyl))porphyrin

α,α,α,α-5,10,15,20-tetrakis-(2-(N-[(2-t-butylcarbamoyl)ethanamide]phenyl))porphyrin

Conditions
ConditionsYield
With 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at -5 - 20℃; for 50h; Condensation;100%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane Inert atmosphere; Cooling with ice;62%
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane
BOC-glycine
4530-20-5

BOC-glycine

H-Ala-Glu(OBzl)-OBzl hydrochloride

H-Ala-Glu(OBzl)-OBzl hydrochloride

Boc-Gly-Ala-Glu(OBzl)-OBzl
125274-43-3

Boc-Gly-Ala-Glu(OBzl)-OBzl

Conditions
ConditionsYield
Stage #1: H-Ala-Glu(OBzl)-OBzl hydrochloride With triethylamine In dichloromethane Hydrolysis;
Stage #2: BOC-glycine With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 0 - 25℃; for 14h; Condensation;
100%
BOC-glycine
4530-20-5

BOC-glycine

phenethylamine
64-04-0

phenethylamine

tert-butyl N-{[(2-phenylethyl)carbamoyl]methyl}carbamate
613675-75-5

tert-butyl N-{[(2-phenylethyl)carbamoyl]methyl}carbamate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In acetonitrile at 0 - 20℃; Acylation;100%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine In ethyl acetate at 20℃; for 72h;94%
Stage #1: BOC-glycine With 1,1'-carbonyldiimidazole In dichloromethane at 20℃; for 1h;
Stage #2: phenethylamine In dichloromethane for 16h;
81%
Stage #1: BOC-glycine With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine In N,N-dimethyl-formamide at 20℃; for 0.5h;
Stage #2: phenethylamine In N,N-dimethyl-formamide at 20℃;
72%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 23℃; for 4h; Inert atmosphere;71%
1-aza-18-crown-6
33941-15-0

1-aza-18-crown-6

BOC-glycine
4530-20-5

BOC-glycine

[2-oxo-2-(1,4,7,10,13-pentaoxa-16-aza-cyclooctadec-16-yl)-ethyl]-carbamic acid tert-butyl ester
394208-14-1

[2-oxo-2-(1,4,7,10,13-pentaoxa-16-aza-cyclooctadec-16-yl)-ethyl]-carbamic acid tert-butyl ester

Conditions
ConditionsYield
With bis(trichloromethyl) carbonate; lutidine In tetrahydrofuran at 25 - 50℃; for 2h;100%
With 2,6-dimethylpyridine; bis(trichloromethyl) carbonate In tetrahydrofuran Inert atmosphere;
BOC-glycine
4530-20-5

BOC-glycine

4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl alcohol
172611-73-3

4-{N-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino}benzyl alcohol

tert-butoxycarbonylamino-acetic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester

tert-butoxycarbonylamino-acetic acid 4-[1-(4,4-dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butylamino]-benzyl ester

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 24h;100%
BOC-glycine
4530-20-5

BOC-glycine

4,6-O-di(tert-butyl)silanediyl-D-glucal
191593-14-3

4,6-O-di(tert-butyl)silanediyl-D-glucal

3-O-(N-tert-butoxycarbonyl-2'-amino-ethanoyl)-4,6-O-di-tert-butylsilanediyl-D-glucal
848359-00-2

3-O-(N-tert-butoxycarbonyl-2'-amino-ethanoyl)-4,6-O-di-tert-butylsilanediyl-D-glucal

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane100%
BOC-glycine
4530-20-5

BOC-glycine

Propargylamine
2450-71-7

Propargylamine

tert-butyl (2-oxo-2-(prop-2-yn-1-ylamino)ethyl)carbamate
847490-49-7

tert-butyl (2-oxo-2-(prop-2-yn-1-ylamino)ethyl)carbamate

Conditions
ConditionsYield
With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 6h; Inert atmosphere;100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h; Inert atmosphere;99%
With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide In acetonitrile at 20℃;96%
BOC-glycine
4530-20-5

BOC-glycine

anthranilic acid
118-92-3

anthranilic acid

2-methoxyethylamine
109-85-3

2-methoxyethylamine

2-aminomethyl-3-(2-methoxyethyl)-3H-quinazolin-4-one

2-aminomethyl-3-(2-methoxyethyl)-3H-quinazolin-4-one

Conditions
ConditionsYield
Stage #1: BOC-glycine; anthranilic acid With pyridine; triphenyl phosphite at 150℃; for 0.166667h; microwave irradiation;
Stage #2: 2-methoxyethylamine at 220℃; for 0.0666667h; microwave irradiation;
100%
BOC-glycine
4530-20-5

BOC-glycine

anthranilic acid
118-92-3

anthranilic acid

2-methoxyethylamine
109-85-3

2-methoxyethylamine

[3-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazolin-2-yl-methyl]carbamic acid tert-butyl ester

[3-(2-methoxyethyl)-4-oxo-3,4-dihydroquinazolin-2-yl-methyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
Stage #1: BOC-glycine; anthranilic acid With pyridine; triphenyl phosphite at 150℃; for 0.166667h; microwave irradiation;
Stage #2: 2-methoxyethylamine at 180℃; for 0.05h; microwave irradiation;
100%
(3S,10R,16S)-16-{(1R)-3-[4-(hydroxymethyl)phenyl]-1-methylallyl}-3-isobutyl-10-(4-methoxybenzyl)-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone
916452-54-5

(3S,10R,16S)-16-{(1R)-3-[4-(hydroxymethyl)phenyl]-1-methylallyl}-3-isobutyl-10-(4-methoxybenzyl)-1-oxa-4,8,11-triazacyclohexadec-13-ene-2,5,9,12-tetraone

BOC-glycine
4530-20-5

BOC-glycine

tert-butoxycarbonylamino-acetic acid 4-{3-[3-isobutyl-10-(4-methoxy-benzyl)-2,5,9,12-tetraoxo-1-oxa-4,8,11-triaza-cyclohexadec-13-en-16-yl]-but-1-enyl}-benzyl ester
916452-55-6

tert-butoxycarbonylamino-acetic acid 4-{3-[3-isobutyl-10-(4-methoxy-benzyl)-2,5,9,12-tetraoxo-1-oxa-4,8,11-triaza-cyclohexadec-13-en-16-yl]-but-1-enyl}-benzyl ester

Conditions
ConditionsYield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h;100%
BOC-glycine
4530-20-5

BOC-glycine

trans-7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-amine

trans-7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-amine

[[[(trans-7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-yl)amino]carbonyl]methyl]carbamic acid 1,1-dimethylethyl ester

[[[(trans-7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-yl)amino]carbonyl]methyl]carbamic acid 1,1-dimethylethyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane for 3h; pH=9;100%
BOC-glycine
4530-20-5

BOC-glycine

2-(N-t-butoxycarbonylamino)thioacetamide
89226-13-1

2-(N-t-butoxycarbonylamino)thioacetamide

Conditions
ConditionsYield
With Lawessons reagent In dichloromethane at 25℃; for 16h;100%
Stage #1: BOC-glycine With ammonium hydroxide; triethylamine; isobutyl chloroformate In tetrahydrofuran
Stage #2: With tetraphosphorus decasulfide; sodium carbonate In tetrahydrofuran
83%
Multi-step reaction with 3 steps
1: Et3N / tetrahydrofuran / 0.42 h / -10 °C
2: aq. MH3 / tetrahydrofuran / 0.75 h / -10 °C
3: 85 percent / Lawesson's reagent / CH2Cl2 / 16 h / Ambient temperature
View Scheme
BOC-glycine
4530-20-5

BOC-glycine

p-aminoiodobenzene
540-37-4

p-aminoiodobenzene

[(4-iodophenylcarbamoyl)methyl]carbamic acid tert-butyl ester
216774-64-0

[(4-iodophenylcarbamoyl)methyl]carbamic acid tert-butyl ester

Conditions
ConditionsYield
With dacarbazine; dmap In dichloromethane100%
With dmap; diisopropyl-carbodiimide In dichloromethane for 20h; Inert atmosphere;100%
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In dichloromethane at 20℃; for 5h;98%
BOC-glycine
4530-20-5

BOC-glycine

bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride
68641-49-6

bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

(R*)-N-[[2-[N-[(1,1-Dimethylethoxy)carbonyl]glycyl]-1,2,3,4-tetrahydro-3-isoquinolinyl]carbonyl]-L-methionine

(R*)-N-[[2-[N-[(1,1-Dimethylethoxy)carbonyl]glycyl]-1,2,3,4-tetrahydro-3-isoquinolinyl]carbonyl]-L-methionine

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane100%
BOC-glycine
4530-20-5

BOC-glycine

N,N-didodecylamine
3007-31-6

N,N-didodecylamine

C31H62N2O3
879004-97-4

C31H62N2O3

Conditions
ConditionsYield
With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 5h;100%
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