Novel water soluble 2,6-dimethoxyphenyl ester derivatives with intravenous anaesthetic activity
A number of water soluble bis-amino-2,6-dimethoxyphenyl ester derivatives were found to exhibit improved anaesthetic activity in mice relative to propofol 1. Of the analogues disclosed, 44 was further profiled in rodents and found to be a superior agent to propofol for the induction and maintenance of anaesthesia.
Bennett, D. Jonathan,Anderson, Alison,Buchanan, Kirsteen,Byford, Alan,Cooke, Andrew,Gemmell, David K.,Hamilton, Niall M.,Maidment, Maurice S.,McPhail, Petula,Stevenson, Donald F. M.,Sundaram, Hardy,Vijn, Peter
p. 1971 - 1975
(2007/10/03)
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