445470-08-6

Basic information

• Product Name: 2-Chloro-4-phenyl-oxazole
• Synonyms: 2-Chloro-4-phenyl-oxazole
• CAS NO: 445470-08-6
• Molecular Formula: C₉H₆ClNO
• Molecular Weight: 179.61
• Mol File: 445470-08-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Chloro-4-phenyl-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-phenyl-oxazole(445470-08-6)
• EPA Substance Registry System: 2-Chloro-4-phenyl-oxazole(445470-08-6)

Safety Data

• Hazardous Substances Data: 445470-08-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-phenyl-oxazole is used as a reactant for the preparation of arylaminooxazoles, which are known as TRPV1 antagonists. These antagonists play a crucial role in the development of medications targeting pain relief and other conditions associated with the transient receptor potential vanilloid 1 (TRPV1) channel. 2-Chloro-4-phenyl-oxazole's reactivity and structural properties make it a valuable building block in the synthesis of these therapeutic agents.

Upstream product

• 20662-89-9 4-phenyl-1,3-oxazole 

Downstream Products

• 862599-48-2 2-[isocyano-(toluene-4-sulfonyl)-methyl]-4-phenyl-oxazole 
• 887624-09-1 tert-butyl 4-(4-phenyl-1,3-oxazol-2-yl)piperazine-1-carboxylate 
• 1238894-08-0 8-(4-phenyloxazol-2-ylamino)-1,2,3,4-tetrahydronaphthalen-2-ol 
• 116897-05-3 4-phenyl-2-(p-tolyl)-oxazole 

Relevant articles and documents

Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists

The synthesis and structure-activity relationships of a series of 5-monosubstituted and 4,5-disubstituted 2-arylaminooxazoles as novel antagonists of the transient receptor potential vanilloid 1 (TRPV1) receptor are described. The 7-hydroxy group of the t

ARYLOXAZOLE, ARYLOXADIAZOLE AND BENZIMIDAZOLE DERIVATIVES

This invention relates to compounds of the formula wherein X is O or NR8, Y is CR7 or N, and R1 to R8 are as defined in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are associated with the modulation of SST receptors subtype 5.

A two-stage iterative process for the synthesis of poly-oxazoles

(Chemical Equation Presented) Methodology has been developed to prepare bis-oxazoles via a two-stage iterative process. The sequence begins with C 2-chlorination of a lithiated oxazole using hexachloroethane. Generation of the C2-Cs