116897-05-3Relevant academic research and scientific papers
METHOD FOR PRODUCING IODOOXAZOLE COMPOUND, AND METHOD FOR PRODUCING OXAZOLE COMPOUND
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Paragraph 0043-0045, (2021/09/15)
PROBLEM TO BE SOLVED: To produce an iodooxazole compound inexpensively and safely without using oxidizing agents. SOLUTION: On the basis of the following chemical formula (1) an iminoether compound and an iodinating agent are mixed and reacted with each other with light irradiation, to produce an iodooxazole compound. In the formula (1), R1, R2 each denote an aromatic group. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT
A novel synthetic method of 2,4-disubstituted oxazoles using carboxylic acid-derived Bu2Sn[OC(O)R]2
Yoneyama, Hiroki,Oka, Naoki,Usami, Yoshihide,Harusawa, Shinya
supporting information, (2020/05/21)
A novel synthetic method for the preparation of 2,4-disubstituted oxazoles was developed, entailing the reaction of dibutyltin diacylates Bu2Sn[OC(O)R]2 with 1-substituted acetylenes and TMSN3 to afford a range of 2,4-disu
Photochemical Transformation of O-(β-Arylethyl) Arylimidates into 2,4-Diaryl-5-iodoxazoles with 1,3-Diiodo-5,5-dimethylhydantoin
Saito, Aya,Togo, Hideo
, p. 3320 - 3331 (2020/06/01)
Treatment of O-(β-arylethyl) arylimidates with 1,3-diiodo-5,5-dimethylhydantoin (DIH) under irradiation with a tungsten lamp in 1,2-dichloroethane gave the corresponding 2,4-diaryl-5-iodoxazoles and 2,4-diaryloxazoles in good to moderate yields, respectively, depending on the aryl group. It was proposed that the reactions proceeded through the formation of N-iodoimidates by the reaction of O-(β-arylethyl) arylimidates with DIH, followed by the formation of iminyl radicals via homolytic N–I bond cleavage, the 1,5-H shift by the iminyl radicals, the C–I bond formation of the formed carbon-centered radicals with iodine, the nucleophilic cyclization by the imino groups to form 2,4-diaryloxazolines, the oxidation of the formed 2,4-diaryloxazolines to 2,4-diaryloxazoles, and the iodination of the formed 2,4-diaryloxazoles to 2,4-diaryl-5-iodoxazoles with DIH.
Divergent Palladium-Catalyzed Tandem Reaction of Cyanomethyl Benzoates with Arylboronic Acids: Synthesis of Oxazoles and Isocoumarins
Chen, Jiuxi,Chen, Zhongyan,Dai, Ling,Shao, Yinlin,Xiong, Wenzhang,Xu, Tong,Yu, Shuling
supporting information, (2020/04/15)
A palladium-catalyzed tandem reaction of cyanomethyl benzoates with arylboronic acids has been achieved. Substitution at the 2-position of cyanomethyl benzoates was found to be crucial for the selective synthesis of oxazoles and isocoumarins. Cyanomethyl
An iron and copper system catalyzed C-H arylation of azoles with arylboronic acids
Hu, Wei-Ye,Wang, Pei-Pei,Zhang, Song-Lin
supporting information, p. 42 - 48 (2015/02/02)
An efficient, environmentally friendly, and economical new method for arylation reactions of azoles with arylboronic acids via copper-iron-catalyzed C-H and C-B bond activation has been developed. The protocol tolerates a series of functional groups, such as methoxy, nitro, cyano, chloro, and trifluoromethyl groups.
Suzuki coupling of oxazoles
Flegeau, Emmanuel Ferrer,Popkin, Matthew E.,Greaney, Michael F.
, p. 2495 - 2498 (2007/10/03)
A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excel
A novel improved procedure for the synthesis of oxazoles
Huang, Wei,Pei, Jian,Chen, Bingzi,Pei, Weiwei,Ye, Xiulin
, p. 10131 - 10136 (2007/10/03)
In the present work a novel improved and convenient procedure for the synthesis of oxazoles has been developed. Acetamide, instead of ammonium acetate, was used to react with phenacyl benzoates in boiling xylene in the presence of BF3/Et2
