4457-72-1

Basic information

• Product Name: 1,5-DIBROMO-3-METHYLPENTANE
• Synonyms: 1,5-DIBROMO-3-METHYLPENTANE;3-METHYL-1,5-DIBROMOPENTANE;1,5-Dibromo-3-methylpentane,98%;1,5-dibromo-3-methylenepentane
• CAS NO: 4457-72-1
• Molecular Formula: C₆H₁₂Br₂
• Molecular Weight: 243.97
• Mol File: 4457-72-1.mol

Chemical Properties

• Boiling Point: 233℃
• Flash Point: 101°(214°F)
• Appearance: Clear colourless liquid
• Density: 1.6
• Vapor Pressure: 0.0896mmHg at 25°C
• Refractive Index: 1.508-1.51
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility: Insoluble in water.
• CAS DataBase Reference: 1,5-DIBROMO-3-METHYLPENTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-DIBROMO-3-METHYLPENTANE(4457-72-1)
• EPA Substance Registry System: 1,5-DIBROMO-3-METHYLPENTANE(4457-72-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25
• Hazardous Substances Data: 4457-72-1(Hazardous Substances Data)

Usage

Uses

1. Used in Chemical Synthesis:
1,5-Dibromo-3-methylpentane is used as a chemical reagent for the synthesis of various organic compounds. Its unique structure allows it to serve as a building block in the creation of complex molecules, making it a valuable asset in the field of organic chemistry.
2. Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,5-dibromo-3-methylpentane is employed as a pharmaceutical intermediate. It plays a crucial role in the development and production of various drugs, contributing to the advancement of medical treatments and therapies.
3. Used in Pharmaceutical Research:
1,5-Dibromo-3-methylpentane is also utilized in pharmaceutical research, where it aids in the investigation of new drug candidates and the study of their properties. Its unique chemical structure makes it an interesting subject for researchers looking to develop novel therapeutic agents.
4. Used in Solvent Applications:
Due to its liquid state at room temperature, 1,5-dibromo-3-methylpentane can be used as a solvent in various chemical processes. Its ability to dissolve a wide range of substances makes it a versatile option for a variety of applications in the chemical and pharmaceutical industries.

InChI:InChI=1/C6H12Br2/c1-6(2-4-7)3-5-8/h6H,2-5H2,1H3

Upstream product

• 4717-96-8 4-methyltetrahydropyran 
• 6280-15-5 3-methylpentanedial 
• 10138-44-0 2-ethoxy-4-methyl-3,4-dihydro-2H-pyran 
• 4166-53-4 3-methylglutaric anhydride 
• 17037-68-2 (4-methylpiperidin-1-yl)(phenyl)methanone 
• 107-21-1 ethylene glycol 
• 70928-41-5 5-methoxy-3-methyl-pentan-1-ol 
• 6829-42-1 diethyl 3-methylglutarate 
• 4457-71-0 3-methylpentane-1,5-diol 

Downstream Products

• 10250-44-9 1-Brom-3-methyl-5-phthalimido-pentan 
• 5161-17-1 tetrahydro-4-methyl-2H-thiopyran 
• 67512-92-9 4-methylthiane 1,1-dioxide 
• 139294-11-4 1,11-Ditosyloxy-2,6,10-trimethylundecane 
• 66648-70-2 19-methylheptatriacontane 
• 106683-06-1 22-methyltritetracontane 
• 524048-18-8 4-methylcyclohexane-1-carbonitrile 
• 37518-69-7 1,1-diphenyl-4-methylphosphorinanium bromide 
• 54286-13-4 4-methyl-cyclohexane-1,1-dicarboxylic acid 
• 1419386-08-5 C₁₇H₂₂O₃ 
• 1119259-46-9 N-{(S)-6-[(R)-1-(4-Methylpiperidin-1-yl)ethyl]-1,2,3,4-tetrahydronaphthalen-2-yl}-4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzamide 
• 123952-70-5 1,5-Diamino-3-methylpentane 
• 858677-84-6 1-[1-(4-iodo-phenyl)cyclopropyl]-4-methyl-piperidine 
• 868609-91-0 (R)-1'-(4-bromophenyl)-4-methyl-[1,3']-bipiperidinyl 

Relevant articles and documents

PHEROMONES OF INSECTS AND THEIR ANALOGS. XXIX. METHYL-BRANCHED PHEROMONES FROM 4-METHYLTETRAHYDROPYRAN. 4. SYNTHESIS OF (+/-)-15,19,23-TRIMETHYLHEPTATRIACONTANE - A PHEROMONE OF Glossina morsitans morsitans

Racemic 15,19,23-trimethylheptatriacontane (the sex pheromone of the tsetse fly Glossina morsitans morsitans) has been synthesized from 1,5-dibromo-3-methylpentane, a product of the acid hydrolysis of 4-methyltetrahydropyran.

Process intensification-assisted conversion of α,ω-alkanediols to dibromides

The increasingly widespread applications of α,ω-dibromides motivated development of a scalable, inexpensive process to rapidly convert selected α,ω-alkanediols to the corresponding dibromides. Diols were heated with only 48% aq HBr and an organic solvent, using a Dean-Stark apparatus modified to fractionate the azeotropic distillate, thereby maintaining a higher HBr concentration and reaction rate in the pot. Intensified distillation also increased the reaction rate. Various other substrate, solvent, and parameter effects have been discovered and rationalized.

Light-mediated deoxygenation of alcohols with a dimeric gold catalyst

A new protocol for the reductive deoxygenation of primary alcohols was explored. This photo-mediated method combines a novel approach to bromination of alcohols merged with the powerful reducing capability of [Au2(dppm)2]Cl2 [dppm = 1,1-bis(diphenylphosphino)methane] as a photoredox catalyst. The highly efficient methods discussed are marked by the use of UVA light-emitting diodes, which have significantly reduced reaction times and lowered setup cost.

Double-headed sulfur-linked amino acids as first inhibitors for betaine-homocysteine S -methyltransferase 2

Betaine-homocysteine S-methyltransferase 2 (BHMT-2) catalyzes the transfer of a methyl group from S-methylmethionine to l-homocysteine, yielding two molecules of l-methionine. It is one of three homocysteine methyltransferases in mammals, but its overall contribution to homocysteine remethylation and sulfur amino acid homeostasis is not known. Moreover, recombinant BHMT-2 is highly unstable, which has slowed research on its structural and catalytic properties. In this study, we have prepared the first series of BHMT-2 inhibitors to be described, and we have tested them with human recombinant BHMT-2 that has been stabilized by copurification with human recombinant BHMT. Among the compounds synthesized, (2S,8RS,11RS)-5-thia-2,11-diamino-8-methyldodecanedioic acid (11) was the most potent (Kiapp ～77 nM) and selective inhibitor of BHMT-2. Compound 11 only weakly inhibited human BHMT (IC 50 about 77 μM). This compound (11) may be useful in future in vivo studies to probe the physiological significance of BHMT-2 in sulfur amino acid metabolism.

Synthesis and biological characterization of (Z)-9-heptadecenoic and (Z)-6-methyl-9-heptadecenoic acids: Fatty acids with antibiotic activity produced by Pseudozyma flocculosa

Difficulties in isolating and purifying antibiotic fatty acids from culture filtrates of Pseudozyma flocculosa, a biocontrol agent against powdery mildew, have been limiting factors in studying the properties and understanding the mode of action of the biocontrol agent. We report a new protocol for synthesizing (Z)-9-heptadecenoic and for the first time synthesis of (Z)-6-methyl-9-heptadecenoic acids, two antibiotic fatty acids produced by P. flocculosa. This allowed reproducible and quantifiable means of assaying biological activity of the molecules. In these bioassays, both molecules exhibited antifungal activity corresponding to their expected potency. These new developments should facilitate further studies aimed at deciphering the ecological properties of P. flocculosa.

A Convenient Synthetic Route to Methylated Silacyclohexanes

The von Braun degradation of substituted piperidines is a general and economical route to a variety of substituted primary and secondary α,ω-dibromopentanes.Grignard ring closure procedures have been carried out with seven different dibromopentanes in moderate to good yields.Ring closures with MeClSiCl2 lead to product mixtures which are appreciably enriched in one isomer, affording a convenient entry into a variety of derivatives which can be used for stereochemical studies.Assignment of structures based on 1H NMR and mass spectral fragmentation patterns is discussed