524048-18-8Relevant academic research and scientific papers
Corresponding amine nitrile and method of manufacturing thereof
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, (2017/10/22)
The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.
Cyclohexylcarbonitriles: Diastereoselective arylations with TMPZnCl·LiCl
Mycka, Robert J.,Duez, Stephanie,Bernhardt, Sebastian,Heppekausen, Johannes,Knochel, Paul,Fleming, Fraser F.
, p. 7671 - 7676 (2012/10/30)
Deprotonating substituted cyclohexanecarbonitriles with TMPZnCl·LiCl affords zincated nitriles that diastereoselectively couple with aryl bromides in the presence of catalytic Pd(OAc)2 and S-Phos. Steric and electronic effects influence the dia
