446276-22-8

Basic information

• Product Name: 3-[1,1'-BIPHENYL]-4-YL-1H-PYRAZOLE
• Synonyms: BUTTPARK 34\09-41;3-[1,1'-BIPHENYL]-4-YL-1H-PYRAZOLE;3-biphenyl-4-yl-1H-pyrazole;5-{[1,1-biphenyl]-4-yl}-1H-pyrazole
• CAS NO: 446276-22-8
• Molecular Formula: C₁₅H₁₂N₂
• Molecular Weight: 220.27
• Mol File: 446276-22-8.mol

Chemical Properties

• Melting Point: 160-161°C
• Appearance: /
• CAS DataBase Reference: 3-[1,1'-BIPHENYL]-4-YL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[1,1'-BIPHENYL]-4-YL-1H-PYRAZOLE(446276-22-8)
• EPA Substance Registry System: 3-[1,1'-BIPHENYL]-4-YL-1H-PYRAZOLE(446276-22-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 446276-22-8(Hazardous Substances Data)

Upstream product

• 210885-00-0 3-([1,1'-biphenyl]-4-yl)prop-2-yn-1-ol 
• 138716-22-0 3-(dimethylamino)-1-(biphenyl-4-yl)-2-propen-1-one 

Downstream Products

• 1263040-58-9 3-biphenyl-4-yl-1-phenyl-1H-pyrazole 

Relevant articles and documents

Preparation method of pyrazole derivative (by machine translation)

The preparation method comprises the following steps: mixing an alkyne propyl alcohol derivative, a halogen source, an acid and a solvent, heating and reacting, and reacting to Meyer - Schuster generate the pyrazole derivative. Compared with the prior art, the preparation method disclosed by the invention has 91% the advantages of maximum yield, simple operation, mild conditions, high conversion rate, few byproducts and the like, and provides a brand-new synthetic method for construction of pyrazole compounds. (by machine translation)

Cu(OAc)2·H2O-catalyzed N-arylation of nitrogen-containing heterocycles

In the absence of any additional ligands, the efficient N-arylation of nitrogen-containing heterocycles with aryl iodides catalyzed by relative low catalyst amount of Cu(OAc)2·H2O was developed. This simple catalytic system is involved in the C-N cross-coupling reaction and works for a variety of pyrazole, pyrrole, imidazole, triazole, indole, benzoimidazole, benzotriazole, carbazole, and anilines as well as aryl iodides with different electronic properties. Highly efficient copper(II)-catalyzed N-arylation protocol was established.