- Synthesis and luminescence properties of near-infrared N-heterocyclic luciferin analogues for in vivo optical imaging
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As a means of achieving highly sensitive bioluminescence imaging of deep tissues utilizing the firefly luciferin-luciferase (L-L) reaction, we previously reported a luciferin analogue, AkaLumine, which exhibits high cell-permeability and emits near-infrar
- Saito, Ryohei,Kuchimaru, Takahiro,Higashi, Shoko,Lu, Shijia W.,Kiyama, Masahiro,Iwano, Satoshi,Obata, Rika,Hirano, Takashi,Kizaka-Kondoh, Shinae,Maki, Shojiro A.
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p. 608 - 618
(2019/04/05)
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- NOVEL HETEROCYCLIC COMPOUNDS AND SALTS THEREOF, AND LUMINESCENT SUBSTRATE COMPOSITIONS
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PROBLEM TO BE SOLVED: To provide novel compounds excellent in solubility in a buffer solution having a near-neutral pH and available as luminescent substrates in firefly bioluminescence systems. SOLUTION: The present invention provides heterocyclic compou
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Paragraph 0080; 0081
(2016/10/07)
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- NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHODS FOR USE IN TREATING METABOLIC DISORDERS
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The present invention is directed to novel compounds of formula (I) and their use in treating metabolic diseases.
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Page/Page column 54
(2011/12/14)
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- Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives
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This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.
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