447463-83-4

Basic information

• Product Name: 1-(Bromomethyl)-2-fluoro-3-iodobenzene, alpha-Bromo-2-fluoro-3-iodotoluene
• Synonyms: 1-(Bromomethyl)-2-fluoro-3-iodobenzene, alpha-Bromo-2-fluoro-3-iodotoluene;2-Fluoro-3-iodobenzyl bromide;1-bromomethyl-2-fluoro-3-iodo-benzene
• CAS NO: 447463-83-4
• Molecular Formula: C₇H₅BrFI
• Molecular Weight: 314.9214732
• Mol File: 447463-83-4.mol

Chemical Properties

• Boiling Point: 280.8±30.0 °C(Predicted)
• Appearance: /
• Density: 2.168±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(Bromomethyl)-2-fluoro-3-iodobenzene, alpha-Bromo-2-fluoro-3-iodotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Bromomethyl)-2-fluoro-3-iodobenzene, alpha-Bromo-2-fluoro-3-iodotoluene(447463-83-4)
• EPA Substance Registry System: 1-(Bromomethyl)-2-fluoro-3-iodobenzene, alpha-Bromo-2-fluoro-3-iodotoluene(447463-83-4)

Safety Data

• Hazardous Substances Data: 447463-83-4(Hazardous Substances Data)

Usage

Structure

A benzene ring with a bromine atom at the 1st position, a fluorine atom at the 2nd position, and an iodine atom at the 3rd position, with a bromine-attached methyl group at the 1st position.

Structure

A toluene molecule (a benzene ring with a methyl group at the 1st position) with a bromine atom at the 1st position, a fluorine atom at the 2nd position, and an iodine atom at the 3rd position.

Functional groups

Bromomethyl, fluoro, and iodo groups.

Functional groups

Bromo, fluoro, and iodo groups.

Applications

Used as a building block in the production of various pharmaceutical drugs and as an intermediate in organic synthesis.

Applications

Used as an intermediate in the development of new chemical compounds, with potential applications in the pharmaceutical and agrochemical industries.

Hazardous nature

Must be handled with care due to its toxic and hazardous nature.

Hazardous nature

Must be handled with care due to its toxic and hazardous nature.

Upstream product

• 348-52-7 1-Fluoro-2-iodobenzene 
• 307975-02-6 (2-fluoro-3-iodo-phenyl)-methanol 
• 447464-03-1 2-fluoro-3-iodobenzoic acid 

Downstream Products

• 447463-29-8 (3-{4-[1-(2-fluoro-3-iodo-benzyloxy)-ethyl]-2-methoxy-5-nitro-phenoxy}-propyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Biphenyl compound as well as preparation method and medical application thereof

The invention discloses a biphenyl compound as well as a preparation method and medical application thereof, the structure of the biphenyl compound is shown as a formula (I) or a formula (II), and thebiphenyl compound or pharmaceutically acceptable salt, tautomer, meso-isomer, raceme, stereoisomer, metabolite, metabolite precursor, prodrug or solvate thereof is a PD-L1 inhibitor. The compound hasa remarkable inhibiting effect on the interaction of PD-1 and PD-L1 protein, so that the compound can be applied to the preparation of PD-L1 inhibitors and immunomodulator drugs for preventing or treating tumors, autoimmune diseases, organ transplant rejection, infectious diseases and inflammatory diseases.

2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

The present invention relates to 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-yl)picolinamide derivatives of formula (I) wherein Ar1, Q, and R1 to R5 are as described in the description, to their preparation, to

2-(1,2,3-TRIAZOL-2-YL)BENZAMIDE AND 3-(1,2,3-TRIAZOL-2-YL)PICOLINAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

The present invention relates to 2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2- yl)picolinamide derivatives of formula (I) Formula (I) wherein Ar1, Q, and R1 to R5 are as described in the description, to their pre

Discovery of selective metal-binding peptoids using 19F encoded combinatorial libraries

A method for encoding solid-phase split/mix combinatorial libraries using the chemical shift of synthetic fluoroarenes ('F-codes') has been developed. They have wide chemical shift dispersion and are detectable at the sub-μmol level. 19F NMR is