348-52-7

Basic information

• Product Name: 1-Fluoro-2-iodobenzene
• Synonyms: 1-fluoro-2-iodo-benzen;O-FLUOROIODOBENZENE;O-IODO FLUOROBENZENE;2-FLUOROIODOBENZENE;1-FLUORO-2-IODOBENZENE;1-fluor-2-oiodobenzene;2-iodofluorobenzene;1-Fluoro-2-iodobenzene,99%
• CAS NO: 348-52-7
• Molecular Formula: C₆H₄FI
• Molecular Weight: 222
• EINECS: 206-477-3
• Product Categories: Aromatic Esters;Fluorobenzene;Miscellaneous;Fluorine Compounds;Iodine Compounds;Aryl;C6;Halogenated Hydrocarbons;Aryl Fluorinated Building Blocks;Building Blocks;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Hydrocarbons;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks
• Mol File: 348-52-7.mol
• Article Data: 27

Chemical Properties

• Melting Point: −41-−40 °C(lit.)
• Boiling Point: 188-189 °C(lit.)
• Flash Point: 160 °F
• Appearance: Clear light yellow/Liquid
• Density: 1.903 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.791mmHg at 25°C
• Refractive Index: n20/D 1.59(lit.)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive: Light Sensitive
• BRN: 2039770
• CAS DataBase Reference: 1-Fluoro-2-iodobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Fluoro-2-iodobenzene(348-52-7)
• EPA Substance Registry System: 1-Fluoro-2-iodobenzene(348-52-7)

Safety Data

• Hazard Codes: Xn,N,Xi
• Statements: 22-37/38-41-51/53-36/37/38
• Safety Statements: 26-39-61-37/39
• RIDADR: UN3082 - class 9 - PG 3 - DOT NA1993 - Environmentally hazardous
• WGK Germany: 2
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 348-52-7(Hazardous Substances Data)

Usage

Chemical Properties

Clear colourless to light yellow liquid

Uses

Different sources of media describe the Uses of 348-52-7 differently. You can refer to the following data:
1. suzuki reaction
2. 2-Fluoroiodobenzene was used in the synthesis of:bridged biphenyl compounds, 1-fluoro-8-methylbiphenylene and 4-fluoro-5-methylfluorene2-acetyl-7-iodo-1-benzothiophenechiral o-phosphanophenyl sulfoxides

Synthesis Reference(s)

Synthetic Communications, 20, p. 1701, 1990 DOI: 10.1080/00397919008053092

Upstream product

• 462-06-6 fluorobenzene 
• 7647-01-0 hydrogenchloride 
• 348-54-9 2-Fluoroaniline 
• 56-23-5 tetrachloromethane 
• 7790-99-0 Iodine monochloride 
• 1842-26-8 (2-fluorophenyl)trimethylsilane 
• 445-29-4 o-fluoro-benzoic acid 
• 1993-03-9 o-fluorophenylboronic acid 
• 696-62-8 para-iodoanisole 
• 393-52-2 2-Fluorobenzoyl chloride 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 1034926-54-9 bis(2-fluorophenyl)iodonium tetrafluoroborate 
• 2926-29-6 Langlois reagent 
• 128254-27-3 2-Fluoro-1,4-bis-trimethylsilanyl-benzene 

Downstream Products

• 55258-70-3 C₁₄H₁₃FO 
• 55258-68-9 2'-fluoro-4-isopropyldiphenyl ether 
• 3794-15-8 1-benzyl-2-fluorobenzene 
• 445-27-2 2'-Fluoroacetophenone 
• 102276-85-7 Cyano-(2-fluoro-phenyl)-acetic acid ethyl ester 
• 312-05-0 2-Fluorphenylphosphonsaeurediethylester 
• 446-49-1 1-ethyl-2-fluorobenzene 
• 61317-65-5 1-(2,2-difluorovinyl)-2-fluorobenzene 
• 200001-67-8 7-(2-fluorophenyl)-7-norbornanol 
• 208183-93-1 3-(2-fluorophenyl)-prop-2-yn-1-ol 
• 220925-03-1 (S)-2-fluorophenyl p-tolyl sulfoxide 
• 220925-04-2 (S)-2-fluorophenyl 2-methoxy-1-naphthyl sulfoxide 
• 362-54-9 2-fluorobenzhydrol 
• 149733-71-1 (E)-3-(2-fluorophenyl)acrylaldehyde 

Relevant articles and documents

Selective C-H Iodination of (Hetero)arenes

Iodoarenes are versatile intermediates and common synthetic targets in organic synthesis. Here, we present a strategy for selective C-H iodination of (hetero)arenes with a broad functional group tolerance. We demonstrate the utility and differentiation to other iodination methods of supposed sulfonyl hypoiodites for a set of carboarenes and heteroarenes.

Utilising Sodium-Mediated Ferration for Regioselective Functionalisation of Fluoroarenes via C?H and C?F Bond Activations

Pairing iron bis(amide) Fe(HMDS)2 with Na(HMDS) to form new sodium ferrate base [(dioxane)0.5?NaFe(HMDS)3] (1) enables regioselective mono and di-ferration (via direct Fe?H exchange) of a wide range of fluoroaromatic substrates under mild reaction conditions. Trapping of several ferrated intermediates has provided key insight into how synchronised Na/Fe cooperation operates in these transformations. Furthermore, using excess 1 at 80 °C switches on a remarkable cascade process inducing the collective twofold C?H/threefold C?F bond activations, where each C?H bond is transformed to a C?Fe bond whereas each C?F bond is transformed into a C?N bond.

Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO2) and N-halosuccinimide (NXS) in DMF at room temperature under metal- and acid-free condition is described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide.