449173-27-7Relevant articles and documents
PROTEASOME ACTIVITY ENHANCING COMPOUNDS
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Page/Page column 157-158, (2015/06/03)
The present invention is directed to compounds having the Formula (I), (II), (III), (IV), and (V), compositions thereof, the methods of synthesis of the compouds of interest, and to methods for the treatment of a condition associated with a dysfunction in proteostasis, such as cancer, inflammatory conditions, neurodegeneration, metabolic conditions, comprising administering an effective amount of a compound of the invention.
Synthesis of novel heteroaromatics structurally related to ellipticine alkaloids via thermolysis of pyridannulated enyne-carbodiimides
Lu, Xiaoling,Petersen, Jeffrey L.,Wang, Kung K.
, p. 5412 - 5415 (2007/10/03)
New synthetic pathways to the 5H-pyrido[3',4':4,5]pyrrolo[2,3-b]quinolines 6, the 6H-pyrido[3',4':4,5]pyrrolo[2,3-b] [1,6]naphthyridines 7, and the 11H-pyrido[43,3': 4,5]pyrrolo[2,3-b]quinolines 8 via thermolysis of the pyridannulated enyne-carbodiimides 14, 19, and 23 were established. These novel heteroaromatic systems are structurally related to ellipticine alkaloids and could serve as DNA- intercalating agents.
Transition metal catalyzed synthesis of 5-azaindoles
Xu, Lianhong,Lewis, Iestyn R.,Davidsen, Steven K.,Summers, James B.
, p. 5159 - 5162 (2007/10/03)
In an effort to develop synthetic procedures for the preparation of 2- substituted 5-azaindoles, the synthesis and cyclization reactions of acetylenic aminopyridines was explored. A novel method for the synthesis of 2-substituted 5-azaindoles via a transi