- Synthesis method of 2-chloro-4-fluorotoluene based on honeycomb filler
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The invention discloses a synthesis method of 2-chloro-4-fluorotoluene based on a honeycomb filler. The method comprises the following steps of: carrying out a diazotization reaction by using anhydrous hydrofluoric acid as a solvent, 3-chloro-4-methylaniline as a raw material and nitrogen trioxide as a diazotization reagent, and directly carrying out a thermal decomposition reaction; and after the reaction is finished, standing for layering, adjusting an organic layer to be neutral by using a sodium hydroxide solution, carrying out steam distillation and room-temperature layering, and rectifying the organic layer to obtain a target product. According to the method, the nitrogen trioxide is adopted as the diazotization reagent, the solid waste amount is greatly reduced, no high-salinity wastewater is discharged, the production cost is reduced, and the method is more environment-friendly.
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Paragraph 0020-0034
(2021/10/30)
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- A 2 - chloro -4 - fluoro methylbenzene preparation method (by machine translation)
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The invention discloses a 2 - chloro - 4 - fluoro methylbenzene preparation method. The invention relates to a 2 - chloro - 4 - fluoro methylbenzene preparation method, comprising the following steps: in anhydrous hydrogen fluoride in a solvent, the diazo hydrogen fluoride salt II through a thermal decomposition reaction, to obtain the 2 - chloro - 4 - fluoro-toluene can be III, the thermal decomposition reaction at elevated temperatures in the process, the temperature of the starting point of 0 °C -15 °C, the temperature rise of the end point is 60 - 120 °C, or the thermal decomposition reaction at elevated temperatures to the end point, thermal insulation reaction. The preparation method of the present invention, can be in the anhydrous hydrogen fluoride solvent in pyrolysis, reduces the other impurities, and in a manner fully under stirring pyrolysis, the temperature is controlled, easy to operate, the product has high purity, high yield. (by machine translation)
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Paragraph 0035-0059
(2018/10/19)
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- Preparation of biaryl compounds
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A method for the preparation of biaryl compounds is disclosed which comprises contacting an aromatic halide in the presence of a catalyst comprising zerovalent nickel, a bidentate phosphorus-containing coordinating ligand and a reducing metal in a polar, aprotic solvent system for a time and under conditions suitable for the formation of biaryl compound.
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