452-73-3

Basic information

• Product Name: 2-Chloro-4-fluorotoluene
• Synonyms: 4-FLUORO-2-CHLOROTOLUENE;2-CHLORO-4-FLUOROTOLUENE;2-CHLORO-4-FLUORO-1-METHYLBENZENE;Benzene, 2-chloro-4-fluoro-1-methyl-;2-Chloro-4-fluorotoluene,98%;2-Chloro-4-fluorotoluene 98%;2-CHLORO-3-FLUOROTOLU;1-Chloro-5-fluoro-2-methylbenzene
• CAS NO: 452-73-3
• Molecular Formula: C₇H₆ClF
• Molecular Weight: 144.57
• EINECS: 207-209-8
• Product Categories: Fluorin-contained toluene series;Aromatic Halides (substituted);Benzene series;Halogen toluene;Miscellaneous;Chlorine Compounds;Fluorine Compounds;Aryl;C7;Halogenated Hydrocarbons;API Intermediate
• Mol File: 452-73-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 154-156 °C(lit.)
• Flash Point: 122 °F
• Appearance: colorless to light yellow liquid
• Density: 1.197 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.942mmHg at 25°C
• Refractive Index: n20/D 1.499(lit.)
• Storage Temp.: Flammables area
• BRN: 1931690
• CAS DataBase Reference: 2-Chloro-4-fluorotoluene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-fluorotoluene(452-73-3)
• EPA Substance Registry System: 2-Chloro-4-fluorotoluene(452-73-3)

Safety Data

• Hazard Codes: Xi,F
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39-36
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 452-73-3(Hazardous Substances Data)

Usage

Chemical Properties

colorless to light yellow liqui

Uses

2-Chloro-4-fluorotoluene has been used in the preparation of 2-chloro-4-fluoro-benzylbromide.

General Description

2-Chloro-4-fluorotoluene generates vibronically excited, jet-cooled benzyl-type radicals by corona excited supersonic expansion coupled with a pinhole-type glass nozzle technique.

InChI:InChI=1/C7H6BrF/c1-5-2-3-6(8)7(9)4-5/h2-4H,1H3

Upstream product

• 95-74-9 3-chloro-p-toluidine 

Downstream Products

• 71171-93-2 9-fluorobenzopyrene 
• 112108-73-3 1-chloro-5-fluoro-2-methyl-4-nitrobenzene 
• 194290-71-6 (4-Chloro-2-fluoro-5-methyl-phenyl)-(3-nitro-phenyl)-methanone 
• 352-32-9 p-fluorotoluene 
• 194291-02-6 (3-Amino-phenyl)-(4-chloro-2-fluoro-5-methyl-phenyl)-methanone 
• 45767-66-6 2-chloro-4-fluorobenzylbromide 
• 1126424-32-5 1-chloro-5-fluoro-4-iodo-2-methylbenzene 
• 367-29-3 3-fluoro-6-methylaniline 
• 177211-26-6 1-(4-chloro-2-fluoro-5-methylphenyl [ring-14C(U)])-ethanone 
• 2252-51-9 2-choro-4-fluorobenzoic acid 
• 93286-22-7 2‐chloro‐4‐fluorobenzyl chloride 
• 1190399-91-7 5-chloro-N²-[2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl]-N⁴-[2-(isopropylsulfonyl)phenyl]pyrimidine-2,4-diamine dihydrochloride 

Relevant articles and documents

Synthesis method of 2-chloro-4-fluorotoluene based on honeycomb filler

The invention discloses a synthesis method of 2-chloro-4-fluorotoluene based on a honeycomb filler. The method comprises the following steps of: carrying out a diazotization reaction by using anhydrous hydrofluoric acid as a solvent, 3-chloro-4-methylaniline as a raw material and nitrogen trioxide as a diazotization reagent, and directly carrying out a thermal decomposition reaction; and after the reaction is finished, standing for layering, adjusting an organic layer to be neutral by using a sodium hydroxide solution, carrying out steam distillation and room-temperature layering, and rectifying the organic layer to obtain a target product. According to the method, the nitrogen trioxide is adopted as the diazotization reagent, the solid waste amount is greatly reduced, no high-salinity wastewater is discharged, the production cost is reduced, and the method is more environment-friendly.

Preparation of biaryl compounds

A method for the preparation of biaryl compounds is disclosed which comprises contacting an aromatic halide in the presence of a catalyst comprising zerovalent nickel, a bidentate phosphorus-containing coordinating ligand and a reducing metal in a polar, aprotic solvent system for a time and under conditions suitable for the formation of biaryl compound.