454685-37-1 Usage
Uses
Used in Medicinal Chemistry:
5-(3-Bromophenylamino)pyrimidine-4,6-diol is used as a potential candidate in medicinal chemistry for its possible biological interactions with enzymes or receptors. The presence of the bromophenylamino group and the pyrimidine-4,6-diol moiety in its structure suggests that it may have therapeutic applications once its properties are fully explored.
Used in Drug Development:
In the field of drug development, 5-(3-Bromophenylamino)pyrimidine-4,6-diol is utilized as a compound of interest for the discovery of new pharmaceutical agents. Its unique molecular structure may contribute to the development of drugs targeting specific biological pathways or receptors, pending further research and validation of its potential effects.
Check Digit Verification of cas no
The CAS Registry Mumber 454685-37-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,4,6,8 and 5 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 454685-37:
(8*4)+(7*5)+(6*4)+(5*6)+(4*8)+(3*5)+(2*3)+(1*7)=181
181 % 10 = 1
So 454685-37-1 is a valid CAS Registry Number.
454685-37-1Relevant articles and documents
Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors
Gomtsyan, Arthur,Didomenico, Stanley,Lee, Chih-Hung,Matulenko, Mark A.,Kim, Ki,Kowaluk, Elizabeth A.,Wismer, Carol T.,Mikusa, Joe,Yu, Haixia,Kohlhaas, Kathy,Jarvis, Michael F.,Bhagwatt, Shripad S.
, p. 3639 - 3648 (2007/10/03)
Adenosine (ADO) is an extracellular signaling molecule within the central and peripheral nervous system. Its concentration is increased at sites of tissue injury and inflammation. One of the mechanisms by which antinociceptive and antiinflammatory effects of ADO can be enhanced consists of inhibition of adenosine kinase (AK), the primary metabolic enzyme for ADO. Novel nonnucleoside AK inhibitors based on 4-amino-6-alkynylpyrimidines were prepared, and the importance of the length of the linker at the 5-position for high affinity AK inhibition was demonstrated. Compounds with 2- and 3-atom linkers were the most potent AK inhibitors. Optimization of their physicochemical properties led to 31a and 37a that effectively reduced pain and inflammation in animal models.
