45588-79-2

Basic information

• Product Name: 4-(AMINOMETHYL)-PYRIMIDINE
• Synonyms: 4-(AMINOMETHYL)-PYRIMIDINE;4-PYRIMIDINE METHANAMINE;4-Pyrimidinemethanamine (9CI);pyrimidin-4-ylmethanamine;(pyrimidin-4-ylmethyl)amine(SALTDATA: 2HCl);(pyrimidin-4-ylmethyl)amine dihydrochloride;C-Pyrimidin-4-yl-methylamine
• CAS NO: 45588-79-2
• Molecular Formula: C₅H₇N₃
• Molecular Weight: 109.13
• Product Categories: PYRIMIDINE;Pyrimidine series;Heterocycle-Pyrimidine series
• Mol File: 45588-79-2.mol

Chemical Properties

• Boiling Point: 224.323 °C at 760 mmHg
• Flash Point: 112.07 °C
• Appearance: /
• Density: 1.138 g/cm³
• Vapor Pressure: 0.092mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.46±0.29(Predicted)
• CAS DataBase Reference: 4-(AMINOMETHYL)-PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(AMINOMETHYL)-PYRIMIDINE(45588-79-2)
• EPA Substance Registry System: 4-(AMINOMETHYL)-PYRIMIDINE(45588-79-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 45588-79-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-(Aminomethyl)-pyrimidine is used as a key intermediate in the synthesis of pharmaceutical drugs, contributing to the development of new medications with enhanced therapeutic properties. Its unique structure allows for the modification of drug molecules, potentially improving their efficacy, selectivity, and pharmacokinetics.
Used in Agricultural Chemicals:
In the agricultural sector, 4-(Aminomethyl)-pyrimidine serves as a precursor in the production of agrochemicals, such as pesticides and herbicides. Its incorporation into these compounds can lead to the development of more effective and environmentally friendly products.
Used in Organic Synthesis:
As a building block in organic synthesis, 4-(Aminomethyl)-pyrimidine is utilized to create a variety of compounds with biological activity. Its reactivity and structural features enable the synthesis of novel compounds with potential applications in medicine, agriculture, and other fields.
Used in Drug Development:
4-(Aminomethyl)-pyrimidine holds promise in the development of new drugs and agrochemicals due to its versatile reactivity and ability to modify the properties of other compounds. Its potential applications in this area are vast, as it can be used to design and synthesize innovative molecules with improved therapeutic or pesticidal effects.

InChI:InChI=1/C5H7N3/c6-3-5-1-2-7-4-8-5/h1-2,4H,3,6H2

Upstream product

• 25746-87-6 acetal dimethylique du pyrimidine-4 carboxaldehyde 

Downstream Products

• 82298-80-4 N-Pyrimidin-4-ylmethyl-formamide 
• 676993-87-6 6-(3-chloro-phenylamino)-4-isopropyl-N-pyrimidin-4-ylmethyl-nicotinamide 
• 105918-10-3 3-[3-[N-(4-fluorobenzyl)-N-pyrid-2-ylamino]propylamino]-4-pyrimidin-4-ylmethylamino-1,2,5-thiadiazole-1-oxide 
• 530090-27-8 (Z)-2-{1-[2-chloro-4-(3-methyl-1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}-N-(pyrimidin-4-ylmethyl)acetamide 
• 1254308-89-8 C₃₀H₂₉N₇O₂ 
• 1316759-08-6 4-[4-[2-[(3S)-3-hydroxyquinuclidin-3-yl]ethynyl]phenoxy]-N-(pyrimidin-4-ylmethyl)benzamide 
• 1316759-18-8 C₂₇H₂₆N₄O₂ 
• 1372590-12-9 3-{2-[methyl(methylsulfonyl)amino]phenyl}-11-oxo-N-(pyrimidin-4-ylmethyl)-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepine-7-carboxamide 
• 1611472-75-3 8-(4-chlorophenyl)-N-(pyrimidin-4-ylmethyl)-1,6-naphthyridine-2-carboxamide 

Relevant articles and documents

1,2,3-TRIAZOLOAZINES ET AUTRES HETEROCYCLES AZOTES DERIVES D'AZINE-CARBOXALDEHYDES

α-(N)-azine-carboxaldehydes are convenient precursors of 1,2,3-triazoloazines.Through oxidative cyclisation of the corresponding hydrazones we have prepared the new 1,2,3-triazolopyridazine and 1,2,3-triazolopyrazine.Unlike the other azaindolizines these compounds are degraded by electrophiles. attempts to prepare imidazopyrimidine or derivatives have been carried out either from 4-aminomethylpyrimidine or from ethyl 2-(4-pyrimidinyl)propionate.