4-(AMINOMETHYL)-PYRIMIDINE

Base Information

• Chemical Name: 4-(AMINOMETHYL)-PYRIMIDINE
• CAS No.: 45588-79-2
• Molecular Formula: C5H7 N3
• Molecular Weight: 109.131
• Hs Code.: 2933599090
• Mol file: 45588-79-2.mol

Synonyms:(4-Pyrimidinylmethyl)amine;4-Aminomethylpyrimidine

Chemical Property of 4-(AMINOMETHYL)-PYRIMIDINE

Chemical Property:

• Vapor Pressure: 0.092mmHg at 25°C
• Refractive Index: 1.558
• Boiling Point: 224.323 °C at 760 mmHg
• PKA: 7.46±0.29(Predicted)
• Flash Point: 112.07 °C
• PSA: 51.80000
• Density: 1.138 g/cm³
• LogP: 0.63560
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

99% ^*data from raw suppliers

4-(Aminomethyl)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(AMINOMETHYL)-PYRIMIDINE

There total 1 articles about 4-(AMINOMETHYL)-PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetal dimethylique du pyrimidine-4 carboxaldehyde (25746-87-6) → 1-(pyrimidin-4-yl)methanamine (45588-79-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) cc. H₂SO₄; 2.) NH₂OH / 1.) H₂O, 70 deg C, 1.5 h; 2.) H₂O, 12 h, r.t., pH=8-9

2: H₂ / 10percent Pd-C / methanol / 6 h / 760 Torr / Ambient temperature

With sulfuric acid; hydrogen; hydroxylamine; palladium on activated charcoal; In methanol;

Reference yield: 80.0%

1-(pyrimidin-4-yl)methanamine (45588-79-2) + N-{3-[(3,5-dimethylphenyl)sulfonyl]-5-chloro-1H-indole-2-carbonyl}-D,L-alanine (742106-26-9) → 5-chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyrimidin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 12h;

DOI:10.1021/acs.jmedchem.6b01906

Reference yield: 77.0%

1-(pyrimidin-4-yl)methanamine (45588-79-2) + 5-chloro-3-(3,5-dimethylphenyl-sulfonyl)indole-2-carboxylic acid (473257-46-4) → 5-chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(pyrimidin-4-ylmethyl)-1H-indole-2-carboxamide

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 12h;

DOI:10.1021/jm5011622

upstream raw materials:

acetal dimethylique du pyrimidine-4 carboxaldehyde

Downstream raw materials:

N-Pyrimidin-4-ylmethyl-formamide

6-(3-chloro-phenylamino)-4-isopropyl-N-pyrimidin-4-ylmethyl-nicotinamide

3-[3-[N-(4-fluorobenzyl)-N-pyrid-2-ylamino]propylamino]-4-pyrimidin-4-ylmethylamino-1,2,5-thiadiazole-1-oxide

(Z)-2-{1-[2-chloro-4-(3-methyl-1H-pyrazol-1-yl)benzoyl]-4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene}-N-(pyrimidin-4-ylmethyl)acetamide

Refernces